The Great London [Search results for Biology] 

The first eukaryote is thought to have arisen when simpler archaea and bacteria joined forces. But in an Opinion paper published in >Trends in Cell Biology, researchers propose that new genomic evidence derived from a deep-sea vent on the ocean floor suggests that the molecular machinery essential to eukaryotic life was probably borrowed, little by little over time, from those simpler ancestors.

"We are beginning to think of eukaryotic origins as a slow process of growing intimacy--the result of a long, slow dance between kingdoms, and not a quick tryst, which is the way it is portrayed in textbooks," says Mukund Thattai of the National Centre for Biological Sciences in India.

The eukaryotic cells of plants, animals, and protists are markedly different from those of their single-celled, prokaryotic relatives, the archaea and bacteria. Eukaryotic cells are much larger and have considerably more internal complexity, including many internal membrane-bound compartments.

Although scientists generally agree that eukaryotes can trace their ancestry to a merger between archaea and bacteria, there's been considerable disagreement about what the first eukaryote and its immediate ancestors must have looked like. As Thattai and his colleagues Buzz Baum and Gautam Dey of University College London explain in their paper, that uncertainty has stemmed in large part from the lack of known intermediates that bridge the gap in size and complexity between prokaryotic precursors and eukaryotes. As a result, they say, the origin of the first eukaryotic cell has remained "one of the most enduring mysteries in modern biology."

That began to change last year with the discovery of DNA sequences for an organism that no one has ever actually seen living near a deep-sea vent on the ocean floor. The genome of the archaeon known as Lokiarchaeum ('Loki' for short) contains more "eukaryotic signature proteins" (ESPs) than any other prokaryote. Importantly, among those ESPs are proteins (small Ras/Arf-type GTPases) critical for eukaryotes' ability to direct traffic amongst all those intercellular compartments.

The authors consider the available data to explore an essential question: what might the archaeal ancestor of all eukaryotes look like? "If we could turn back the clock and peer inside this cell, would its cellular organization have been like that of an archaeal cell or more eukaryote-like?" Dey says.

As the closest known archaeal relative of eukaryotes, Loki helps to answer that question. The researchers say that the ESPs found in Loki are unlikely to work in the same way they do in eukarytoes. That's because Loki doesn't appear to have enzymes required for ESP association with membranes or key building blocks of the membrane trafficking machinery.

"However," Baum says, "the genome can be seen as 'primed' for eukaryogenesis. With the acquisition of a number of key genes and lipids from a bacterial symbiont, it would be possible for Loki-type cells to evolve a primitive membrane trafficking machinery and compartmentalization."

The researchers predict that, when Loki is finally isolated or cultured, "it will look more like an archaeon than a proto-eukaryote and will not have internal compartments or a vesicle-trafficking network." But its morphology and/or cell cycle might have complexities more often associated with eukaryotes.

Baum and Dey say they now plan to explore the basic cell biology of the related archaea Sulfolobus acidocaldarius, first isolated from an acidic hot spring in Yellowstone National Park.

"We believe it will be very difficult to crack the mysteries of eukaryogenesis without first understanding the archaeal cell biology," Dey says. "We are currently developing tools in the lab to study the cell cycle and cellular morphology of Sulfolobus at the single-cell level under the microscope. We would also love to catch a glimpse of Loki."

Source: Cell Press [June 16, 2016]

Typically ignored, the millions of microorganisms that we tread upon daily play a major role in the decomposition of soil matter -- one that is of far greater significance than that of the whales and pandas that tend to steal our attention. A group of researchers has just shown that there is an enormous diversity among a group of bacteria-eating microorganisms known as Cercozoa. In four small soil samples, each consisting of a half gram of soil, they discovered more than 1000 different species per sample. The research suggests that a drier climate in the years ahead due to climate change will contribute to a shift in the number of soil microorganisms, and thus, a shift in the decomposition of soil matter, with as of yet to be known consequences.

A team led by researchers from the Section for Terrestrial Ecology (Flemming Ekelund, Christopher B. Harder and Regin Ronn, at the Department of Biology, University of Copenhagen) has just published an article in the >ISME Journal. The group's studies show that there is enormous species diversity among an oft-overlooked group of organisms known as Cercozoa. In four small soil samples, each consisting of just a half gram of soil, the researchers discovered more than 1000 different species per sample. The research was conducted in collaboration with Section for Microbiology staff (Department of Biology, University of Copenhagen) and the eminent British scientist, David Bass (Natural History Museum, London), and is supported by national research councils and the Carlsberg Foundation.

Associate Professor Flemming Ekelund of the Department of Biology explains, "Cercozoa are small bacteria-eating microorganisms that play a prominent role in soil ecology. Serious interest in these organisms began about 25-30 years ago, as people began to wonder what caused bacteria to disappear from soil. As interest took root, the number of known species increased sharply."

The name Cercozoa is derived from the Greek word, kerkos (tail), as some of the species within the group have a tail like end, and zoon (animal), as these organisms were previously thought to be a type of animal.

A single teaspoon of soil (a couple of grams) contains millions of microorganisms, so it is hopeless to create a species list by studying organisms one by one. Furthermore, many of these organisms belong to species unknown to science.

"We took small soil samples (½-1 gram), from which we analysed DNA strands (genetic material) from hundreds of thousands of organisms" (deep sequencing), explains Christoffer Bugge Harder. "However, it's difficult to catalogue and systematise this huge amount of data. To do so, we used the Section of Microbiology's capacity to deploy specialized statistics tools. Our British colleague, David Bass, contributed precise DNA references for the species in the group that have already been thoroughly catalogued. For now, this remains at just under 1000."

The studies were conducted in correlation with a climate experiment (Climate) that investigates the consequences of climate change in Denmark, as many climate researchers expect it to present itself, by 2075. Besides being able to report an enormous number of species in these samples, the research also demonstrated that a more arid climate, as expected in 2075, will probably lend to a shift in the occurrence of microorganism species; particularly within a group referred to as testate amoebae.

Researchers already know that climate change will result in significant shifts in plant and animal frequency. But it can also lead to changed frequencies among microorganisms, which means that climate change could have an impact on the ecological processes at work in soil. More studies are needed for researchers to specify the impact of an offset and the amount of microorganisms found in soil as a result of global warming.

Source: Faculty of Science - University of Copenhagen [June 21, 2016]

Science has long dictated that brains don't fossilize, so when Nicholas Strausfeld co-authored the first ever report of a fossilized brain in a 2012 edition of Nature, it was met with "a lot of flack."

"It was questioned by many paleontologists, who thought - and in fact some claimed in print - that maybe it was just an artifact or a one-off, implausible fossilization event," said Strausfeld, a Regents' professor in UA's Department of Neuroscience.

His latest paper in Current Biology addresses these doubts head-on, with definitive evidence that, indeed, brains do fossilize.

In the paper, Strausfeld and his collaborators, including Xiaoya Ma of Yunnan Key Laboratory for Palaeobiology at China's Yunnan University and Gregory Edgecombe of the Natural History Museum in London, analyze seven newly discovered fossils of the same species to find, in each, traces of what was undoubtedly a brain.

The species, Fuxianhuia protensa, is an extinct arthropod that roamed the seafloor about 520 million years ago. It would have looked something like a very simple shrimp. And each of the fossils - from the Chengjiang Shales, fossil-rich sites in Southwest China - revealed F. protensa's ancient brain looked a lot like a modern crustacean's, too.

Using scanning electron microscopy, the researchers found that the brains were preserved as flattened carbon films, which, in some fossils, were partially overlaid by tiny iron pyrite crystals. This led the research team to a convincing explanation as to how and why neural tissue fossilizes.

In another recent paper in Philosophical Transactions of the Royal Society B, Strausfeld's experiments uncovered what it likely was about ancient environmental conditions that allowed a brain to fossilize in the first place.

The only way to become fossilized is, first, to get rapidly buried. Hungry scavengers can't eat a carcass if it's buried, and as long as the water is anoxic enough - that is, lacking in oxygen - a buried creature's tissues evade consumption by bacteria as well. Strausfeld and his collaborators suspect F. protensa was buried by rapid, underwater mudslides, a scenario they experimentally recreated by burying sandworms and cockroaches in mud.

This is only step one. Step two, explained Strausfeld, is where most brains would fail: Withstanding the pressure from being rapidly buried under thick, heavy mud.

To have been able to do this, the F. protensa nervous system must have been remarkably dense. In fact, tissues of nervous systems, including brains, are densest in living arthropods. As a small, tightly packed cellular network of fats and proteins, the brain and central nervous system could pass step two, just as did the sandworm and cockroach brains in Strausfeld's lab.

"Dewatering is different from dehydration, and it happens more gradually," said Strausfeld, referring to the process by which pressure from the overlying mud squeezes water out of tissues. "During this process, the brain maintains its overall integrity leading to its gradual flattening and preservation. F. protensa's tissue density appears to have made all the difference."

Now that he and his collaborators have produced unassailable evidence that fossilized arthropod brains are more than just a one-off phenomenon, Strausfeld is working to elucidate the origin and evolution of brains over half a billion years in the past.

"People, especially scientists, make assumptions. The fun thing about science, actually, is to demolish them," said Strausfeld.

Source: University of Arizona [November 06, 2015]

Consider the engineering marvel that is your foot. Be it hairy or homely, without its solid support you'd be hard-pressed to walk or jump normally.

Now, researchers at the Stanford University School of Medicine and the HudsonAlpha Institute for Biotechnology in Huntsville, Alabama, have identified a change in gene expression between humans and primates that may have helped give us this edge when it comes to walking upright. And they did it by studying a tiny fish called the threespine stickleback that has evolved radically different skeletal structures to match environments around the world.

"It's somewhat unusual to have a research project that spans from fish all the way to humans, but it's clear that tweaking the expression levels of molecules called bone morphogenetic proteins can result in significant changes not just in the skeletal armor of the stickleback, but also in the hind-limb development of humans and primates," said David Kingsley, PhD, professor of developmental biology at Stanford. "This change is likely part of the reason why we've evolved from having a grasping hind foot like a chimp to a weight-bearing structure that allows us to walk on two legs."

Kingsley, who is also a Howard Hughes Medical Institute investigator, is the senior author of a paper describing the work that will be >published in Cell. The lead author is former Stanford postdoctoral scholar Vahan Indjeian, PhD, now head of a research group at Imperial College London.

Adapting to different environments

The threespine stickleback is remarkable in that it has evolved to have many different body structures to equip it for life in different parts of the world. It sports an exterior of bony plates and spines that act as armor to protect it from predators. In marine environments, the plates are large and thick; in freshwater, the fish have evolved to have smaller, lighter-weight plates, perhaps to enhance buoyancy, increase body flexibility and better slip out of the grasp of large, hungry insects. Kingsley and his colleagues wanted to identify the regions of the fish's genome responsible for the skeletal differences that have evolved in natural populations.

The researchers identified the area of the genome responsible for controlling armor plate size, and then looked for differences there in 11 pairs of marine and freshwater fish with varying armor-plate sizes. They homed in on a region that includes the gene for a bone morphogenetic protein family member called GDF6. Due to changes in the regulatory DNA sequence near this gene, freshwater sticklebacks express higher levels of GDF6, while their saltwater cousins express less. Strikingly, marine fish genetically engineered to contain the regulatory sequence of freshwater fish expressed higher levels of GDF6 and developed smaller armor plates, the researchers found.

Regulatory regions in humans vs. chimps

Kingsley and his colleagues wondered whether changes in GDF6 expression levels might also have contributed to critical skeletal modifications during human evolution. The possibility was not as far-fetched as it might seem. Other studies by evolutionary biologists, including Kingsley, have shown that small changes in the regulatory regions of key developmental genes can have profound effects in many vertebrates.

They began by working with colleagues in the laboratory of Gill Bejerano, PhD, Stanford associate professor of developmental biology, of computer science and of pediatrics, to compare differences in the genomes of chimps and humans. In previous surveys, they found over 500 places in which humans have lost regulatory regions that are conserved from chimps and many other mammals. Two of these occur near the GDF6 gene. They homed in on one in particular.

"This regulatory information was shared through about 100 million years of evolution," said Kingsley. "And yet, surprisingly, this region is missing in humans."

To learn more about what the GDF6 regulatory region might be controlling, the researchers used the chimp regulatory DNA to control the production of a protein that is easy to visualize in mice. Laboratory mice with the chimp regulatory DNA coupled to the reporter protein strongly and specifically expressed the protein in their hind limbs, but not their forelimbs, and in their lateral toes, but not the big toes of the hind limbs. Mice genetically engineered to lack the ability to produce GDF6 in any part of their bodies had skull bones that were smaller than normal and their toes were shorter than those of their peers. Together, these findings gave the researchers a clue that GDF6 might play a critical role in limb development and evolution.

The big toe: an explanation

The fact that humans are missing the hind-limb-regulatory region probably means that we express less of the gene in our legs and feet during development, but comparable amounts in our nascent arms, hands and skulls. Loss of this particular regulatory sequence would also shorten lateral toes but not the first toe of feet. This may help explain why the big toe is aligned with other short, lateral toes in humans. Such a modification would create a more sturdy foot with which to walk upright.

"These bone morphogenetic proteins are strong signals for bone and cartilage growth in all types of animals," said Kingsley.

"You can evolve new skeletal structures by changing where and when the signals are expressed, and it's very satisfying to see similar regulatory principles in action whether you are changing the armor of a stickleback, or changing specific hind-limb structures during human evolution."

Author: Krista Conger | Source: Stanford University Medical Center [January 07, 2016]

Even if people completely stopped converting tropical forests into farmland, the impacts of tropical deforestation would continue to be felt for many years to come. That's the conclusion of researchers reporting in the Cell Press journal >Current Biology who have used historical rates and patterns of tropical deforestation around the globe to estimate the resulting carbon emissions and species losses over time.

The findings highlight the importance of accounting for the time lag between deforestation and its environmental impacts in meeting conservation goals.

"We show that even if deforestation had completely halted in 2010, time lags ensured there would still be a carbon emissions debt equivalent to five to ten years of global deforestation and an extinction debt of more than 140 bird, mammal, and amphibian forest-specific species, which, if paid, would increase the number of 20th century extinctions in these groups by 120 percent," says Isabel Rosa (@isamdr86) of the Imperial College of London. "Given the magnitude of these debts, commitments to reduce emissions and biodiversity loss are unlikely to be realized without specific actions that directly address this damaging environmental legacy."

It takes time after trees are cut down before the wood and other plant matter left at the site fully decay, releasing carbon into the atmosphere. The resulting loss of habitat also leads to species losses, but those effects also tend to occur gradually.

In the new study, Rosa and her colleagues used a spatially explicit land cover change model to reconstruct the annual rates and spatial patterns of tropical deforestation from 1950 to 2009 in the Amazon, Congo Basin, and Southeast Asia. Using those patterns, they estimated the resulting gross vegetation carbon emissions and species losses.

The findings show that current emissions and species extinctions are mostly tied to past actions. As a result, the researchers explain, changes in annual deforestation rates will initially have a smaller than expected effect on annual carbon emissions. For example, they write, a 30 percent reduction in deforestation rates as seen in the Brazilian Amazon between 2005 and 2010 only cut carbon emissions over the same time period by 10 percent.

The researchers also show that modern deforestation has left us with an estimated extinction debt of 144 vertebrate species found only in tropical forests. That's 20 percent more than the number of extinctions known to have occurred in vertebrate groups in more than a century.

"I expected an increase in both carbon emissions and species extinctions debts, but the magnitude of these debts was surprising," Rosa says.

The findings show that reaching national and global emissions targets will be even more challenging than anticipated.

"We need to do more if we want to avoid paying these debts, thus preventing further loss of species and carbon emissions," Rosa said. "We need to preserve existing habitats, but also restore forests that have been degraded. Allowing the forest to regrow on areas that have been deforested helps by creating 'new' suitable areas for species to survive in while allowing some of this excess carbon to be stored back in the new trees rather than emitted into the atmosphere."

Rosa says she'll continue to pursue the use of their models to support better policy and management decisions.

Source: Cell Press [July 28, 2016]

The first detailed study of a Stegosaurus skull shows that the dinosaur had a stronger bite than suspected, enabling it to eat a wider range of plants than other plant-eating dinosaurs with similarly shaped skulls.

A team of scientists from Bristol, London, Manchester and University of Birmingham compared the skull of 'Sophie', the Natural History Museum's new Stegosaurus specimen, with two other dinosaurs, Plateosaurus and Erlikosaurus, which shared similar skull characteristics. Computer modelling at the University of Bristol showed that, despite looking very similar, the dinosaurs had different biting abilities.

Although the three dinosaurs existed in different time periods and locations and had very differently shaped bodies, all three had similar-looking skulls: a large low snout, feeble peg-shaped teeth, and a scissor-like jaw action only capable of moving up and down. All three ate mainly or exclusively plants.

Until now, it has been assumed that the dinosaurs probably had similar biting abilities and therefore ate similar types of plants. But the research reveals that it can be a trap to assume that because a set of dinosaurs shared a set of similar features, they all operated in the same way – function does not necessarily follow form.

As Prof. Paul Barrett, Merit Researcher at The Natural History Museum explains: 'Our key finding really surprised us: we expected that many of these dinosaur herbivores would have skulls that worked in broadly similar ways. Instead we found that even though the skulls were fairly similar to each other in overall shape, the way they worked during biting was substantially different in each case.'

Stegosaurus lived around 150 million years ago and needed to eat a lot of plants to sustain its large size. As grasses did not exist then, it would have fed on plants such as ferns and horsetails. However the research indicates that it had a much higher bite force than anyone had suspected, enabling it to a wider range of plants than previously thought.

As Barrett, leader of the research team, comments: 'Far from being feeble, as usually thought, Stegosaurus actually had a bite force within the range of living herbivorous mammals, such as sheep and cows.'

This wider range of plants means that scientists need to reconsider how Stegosaurus fitted into its ecological niche. For example it may have had a role in spreading the seeds of cycads – woody ever green plants that were abundant in the time of the dinosaurs and whose seeds are contained in large cones.

Dr David Button, from the University of Birmingham's School of Geography, Earth and Environmental Sciences, said: 'The extra information provided by computing modelling is invaluable. Although we can tell roughly what a dinosaur ate from the shape of its teeth and jaws, the differences highlighted by this study indicate that the biology and ecology of these animals is more complex than we previously thought. As we study the lives of dinosaurs in greater detail, they continue to surprise us.'

Lead author Dr Stephan Lautenschlager, a post-doctoral researcher at the University of Bristol's School of Earth Sciences, employed digital models and computer simulations to analyse the dinosaurs' bites, using data from 3D scans of the skulls and lower jaws. He used engineering software to give the skulls the material properties that would match as closely as possible to the real thing, for example, using data on crocodile teeth to model those of the dinosaurs. By attaching muscles to the models, he was able to examine the forces that the jaws could produce and the subsequent stresses on the skulls.

As computer power increases and software becomes more available, Lautenschlager thinks that we will see more modelling used in dinosaur research: 'Using computer modelling techniques, we were able to reconstruct muscle and bite forces very accurately for the different dinosaurs in our study. As a result, these methods give us new and detailed insights into dinosaur biology – something that would not have been several years ago.'

The findings are published in >Nature Scientific Reports.

Source: University of Birmingham [May 20, 2016]

An intriguing study involving walking stick insects led by the University of Sheffield in England and the University of Colorado Boulder shows how natural selection, the engine of evolution, can also impede the formation of new species.

The team studied a plant-eating stick insect species from California called Timema cristinae known for its cryptic camouflage that allows it to hide from hungry birds, said CU-Boulder Assistant Professor Samuel Flaxman. T. cristinae comes in several different types -- one is green and blends in with the broad green leaves of a particular shrub species, while a second green variant sports a white, vertical stripe that helps disguise it on a different species of shrub with narrow, needle-like leaves.

While Darwinian natural selection has begun pushing the two green forms of walking sticks down separate paths that could lead to the formation of two new species, the team found that a third melanistic, or brown variation of T. cristinae appears to be thwarting the process, said Flaxman. The brown version is known to successfully camouflage itself among the stems of both shrub species inhabited by its green brethren, he said.

Using field investigations, laboratory genetics, modern genome sequencing and computer simulations, the team concluded the brown version of T. cristinae is shuttling enough genes between the green stick insects living on different shrubs to prevent strong divergent adaptation and speciation. The brown variant of the walking stick species also is favored by natural selection because it has a slight advantage in mate selection and a stronger resistance to fungal infections than its green counterparts.

"This is one of the best demonstrations we know of regarding the counteractive effects of natural selection on speciation," said Flaxman of CU-Boulder's Department of Ecology and Evolutionary Biology, second author on the new study. "We show how the brown population essentially carries genes back and forth between the green populations, acting as a genetic bridge that causes a slowdown in divergence."

A paper on the subject appeared in a recent issue of the journal Current Biology. Other study co-authors were from the University of Sheffield, Royal Holloway University of London, Utah State University, the University of Nevada, Reno and the University of Lausanne in Switzerland.

"This movement of genes between environments slows down the genetic divergence of these stick insect populations, impeding the formation of new species," said Aaron Comeault, a former CU-Boulder graduate student and lead study author who conducted the research while at the University of Sheffield. Comeault is now a postdoctoral researcher at the University of North Carolina at Chapel Hill.

The new results underscore how combining natural history and cutting-edge genetics can help researchers gain a better understanding of how evolution operates in nature. It also shows how natural selection can sometimes promote but other times hinder the formation of new species, according to the research team.

Walking sticks are one of nature's oddest insect groups and range in size from the half-inch long T. cristinae to species in Borneo and Vietnam that are more than a foot long. Most walking sticks rely on plant mimicry to protect them from predators.

Source: University of Colorado at Boulder [August 06, 2015]

Placental mammals consist of three main groups that diverged rapidly, evolving in wildly different directions: Afrotheria (for example, elephants and tenrecs), Xenarthra (such as armadillos and sloths) and Boreoeutheria (all other placental mammals). The relationships between them have been a subject of fierce controversy with multiple studies coming to incompatible conclusions over the last decade leading some researchers to suggest that these relationships might be impossible to resolve.

There are thus many outstanding questions such as which is the oldest sibling of the three? Did the mammals go their separate ways due to South America and Africa breaking apart? And if not, when did placentals split up?

"This has been one of the areas of greatest debate in evolutionary biology, with many researchers considering it impossible to resolve," said lead author Dr Tarver of Bristol's School of Earth Sciences. "Now we've proven these problems can be solved -- you just need to analyse genome-scale datasets using models that accurately reflect genomic evolution."

The researchers assembled the largest mammalian phylogenomic dataset ever collected before testing it with a variety of models of molecular evolution, choosing the most robust model and then analysing the data using several supercomputer clusters at the University of Bristol and the University of Texas Advanced Computing Centre. "We tested it to destruction," said Dr Tarver. "We threw the kitchen sink at it."

"A complication in reconstructing evolutionary histories from genomic data is that different parts of genomes can and often do give conflicting accounts of the history," said Dr Siavash Mirarab at the University of California San Diego, USA. "Individual genes within the same species can have different histories. This is one reason why the controversy has stood so long -- many thought the relationships couldn't be resolved."

To address the complexities of analysing large numbers of genes shared among many species, the researchers paired two fundamentally different approaches -- concatenated and coalescent-based analyses -- to confirm the findings. When the dust settled, the team had a specific family tree showing that Atlantogenata (containing the sibling groups of African Afrotheria and the South American Xenarthra) is the sister group to all other placentals.

Because many conflicting family trees have already been published, the team then gathered three of the most influential rivals and tested them against each other with the same model. All of the previous studies suddenly fell into line, their data agreeing with Tarver and colleagues.

With the origins of the family tree resolved, what does this mean for placental mammals? The researchers folded in another layer -- a molecular clock analysis. "The molecular clock analysis uses a combination of fossils and genomic data to estimate when these lineages diverged from each other," said author Dr Mario Dos-Reis of Queen Mary London, UK. "The results show that the afrotherians and xenarthrens diverged from one another around 90 million years ago."

Previously, scientists thought that when Africa and South America separated from each other over 100 million years ago, they broke up the family of placental mammals, who went their separate evolutionary ways divided by geography. But the researchers found that placental mammals didn't split up until after Africa and South America had already separated.

"We propose that South America's living endemic Xenarthra (for exmaple, sloths, anteaters, and armadillos) colonized the island-continent via overwater dispersal," said study author Dr Rob Asher of the University of Cambridge, UK.

Dr Asher suggests that this isn't as difficult as you might think. Mammals are among the great adventurers of the animal kingdom, and at the time the proto-Atlantic was only a few hundred miles wide. We already know that New World monkeys crossed the Atlantic later, when it was much bigger, probably on rafts formed from storm debris. And, of course, mammals repeatedly colonised remote islands like Madagascar.

"You don't always need to overturn the status quo to make a big impact," said Dr Tarver. "All of the competing hypotheses had some evidence to support them -- that's precisely why it was the source of such controversy. Proving the roots of the placental family tree with hard empirical evidence is a massive accomplishment."

The findings are published in Genome Biology and Evolution journal.

Source: University of Bristol [February 15, 2016]

Extra-terrestrials that resemble humans should have evolved on other, Earth-like planets, making it increasingly paradoxical that we still appear to be alone in the universe, the author of a new study on convergent evolution has claimed.

The argument is one of several that emerge from The Runes Of Evolution, a new book in which the leading evolutionary biologist, Professor Simon Conway Morris, makes the case for a ubiquitous "map of life" that governs the way in which all living things develop.

It builds on the established principle of convergent evolution, a widely-supported theory -- although one still disputed by some biologists -- that different species will independently evolve similar features.

Conway Morris argues that convergence is not just common, but everywhere, and that it has governed every aspect of life's development on Earth. Proteins, eyes, limbs, intelligence, tool-making -- even our capacity to experience orgasms -- are, he argues, inevitable once life emerges.

The book claims that evolution is therefore far from random, but a predictable process that operates according to a fairly rigid set of rules.

If that is the case, then it follows that life similar to that on Earth would also develop in the right conditions on other, equivalent planets. Given the growing number of Earth-like planets of which astronomers are now aware, it is increasingly extraordinary that aliens that look and behave something like us have not been found, he suggests.

"Convergence is one of the best arguments for Darwinian adaptation, but its sheer ubiquity has not been appreciated," Professor Conway Morris, who is a Fellow at St John's College, University of Cambridge, said.

"Often, research into convergence is accompanied by exclamations of surprise, describing it as uncanny, remarkable and astonishing. In fact it is everywhere, and that is a remarkable indication that evolution is far from a random process. And if the outcomes of evolution are at least broadly predictable, then what applies on Earth will apply across the Milky Way, and beyond."

Professor Conway Morris has previously raised the prospect that alien life, if out there, would resemble earthlings -- with limbs, heads, and bodies -- notably at a Royal Society Conference in London in 2010. His new book goes even further, however, adding that any Earth-like planet should also evolve thunniform predators (like sharks), pitcher plants, mangroves, and mushrooms, among many other things.

Limbs, brains and intelligence would, similarly, be "almost guaranteed." The traits of human-like intelligence have evolved in other species -- the octopus and some birds, for example, both exhibit social playfulness -- and this, the book suggests, indicates that intelligence is an inevitable consequence of evolution that would characterise extraterrestrials as well.

Underpinning this is Conway Morris' claim that convergence is demonstrable at every major stepping stone in evolutionary history, from early cells, through to the emergence of tissues, sensory systems, limbs, and the ability to make and use tools.

The theory, in essence, is that different species will evolve similar solutions to problems via different paths. A commonly-cited example is the octopus, which has evolved a camera eye that is closely similar to that of humans, although distinctive in important ways that reflect its own history. Although octopi and humans have a common ancestor, possibly a slug-like creature, this lived 550 million years ago and lacked numerous complex features that the two now share. The camera eye of each must therefore have evolved independently.

Conway Morris argues that this process provides an underlying evolutionary framework that defines all life, and leads to innumerable surprises in the natural world. The book cites examples such as collagen, the protein found in connective tissue, which has emerged independently in both fungi and bacteria; or the fact that fruit flies seem to get drunk in the same manner as humans. So too the capacity for disgust in humans -- a hard-wired instinct helping us avoid infection and disease -- is also exhibited by leaf-cutter ants.

The study also identifies many less obvious evolutionary "analogues," where species have evolved certain properties and characteristics that do not appear to be alike, but are actually very similar. For example, "woodpeckerlike habits" are seen in lemurs and extinct marsupials, while the mechanics of an octopus' tentacles are far closer to those of a human arm than we might expect, and even their suckers can operate rather like hands.

Conway Morris contends that all life navigates across this evolutionary map, the basis of what he describes as a "predictive biology." "Biology travels through history," he writes, "but ends up at much the same destination."

This, however, raises fascinating and problematic questions about the possibility of life occurring on other planets. "The number of Earth-like planets seems to be far greater than was thought possible even a few years ago," Conway Morris said. "That doesn't necessarily mean that they have life, because we don't necessarily understand how life originates. The consensus offered by convergence, however, is that life is going to evolve wherever it can."

"I would argue that in any habitable zone that doesn't boil or freeze, intelligent life is going to emerge, because intelligence is convergent. One can say with reasonable confidence that the likelihood of something analogous to a human evolving is really pretty high. And given the number of potential planets that we now have good reason to think exist, even if the dice only come up the right way every one in 100 throws, that still leads to a very large number of intelligences scattered around, that are likely to be similar to us."

If this is so, as the book suggests in its introduction, then it makes Enrico Fermi's famous paradox -- why, if aliens exist, we have not yet been contacted -- even more perplexing. "The almost-certainty of ET being out there means that something does not add up, and badly," Conway Morris said. "We should not be alone, but we are."

The Runes Of Evolution was six years in the making and draws on thousands of academic sources, and throws up numerous other, surprising findings as well. Sabre-teeth, for example, turn out to be convergent, and Conway Morris explains why it is that the clouded leopard of Asia, Neofelis nebulosa, has developed features that could, as it evolves "presage the emergence of a new sabre-tooth," although sadly it looks set to become extinct before this happens. Elsewhere, the study suggests that certain prehistoric creatures other than bats and birds may have attempted to evolve flight.

"It makes people slightly uneasy that evolution can end up reaching the same solutions to questions about how to catch something, how to digest something, and how to work," Conway Morris added. "But while the number of possibilities in evolution in principle is more than astronomical, the number that actually work is an infinitesimally smaller fraction."

The Runes Of Evolution, by Simon Conway Morris, is published by Templeton Press

Source: University of Cambridge [July 02, 2015]

The world's attention is now on Proxima Centauri b, a possibly Earth-like planet orbiting the closest star, 4.22 light-years away. The planet's orbit is just right to allow liquid water on its surface, needed for life. But could it in fact be habitable?

If life is possible there, the planet evolved very different than Earth, say researchers at the University of Washington-based Virtual Planetary Laboratory (VPL) where astronomers, geophysicists, climatologists, evolutionary biologists and others team to study how distant planets might host life.

Astronomers at Queen Mary University in London have announced discovery of Proxima Centauri b, a planet orbiting close to a star 4.22 light-years away. The find has been called "the biggest exoplanet discovery since the discovery of exoplanets."

Rory Barnes, UW research assistant professor of astronomy, published a discussion about the discovery at palereddot.org, a website dedicated to the search for life around Proxima Centauri. His essay describes research underway through the UW planetary lab -- part of the NASA Astrobiology Institute -- to answer the question, is life possible on this world?

"The short answer is, it's complicated," Barnes writes. "Our observations are few, and what we do know allows for a dizzying array of possibilities" -- and almost as many questions.

The Virtual Planetary Laboratory is directed by Victoria Meadows, UW professor of astronomy. UW-affiliated researchers include Giada Arney, Edward Schwieterman and Rodrigo Luger. Using computer models, the researchers studied clues from the orbits of the planet, its system, its host star and apparent companion stars Alpha Centauri A and B -- plus what is known of stellar evolution to begin evaluating Proxima b's chances.

Relatively little is known about Proxima:

• It's at least as massive as Earth and may be several times more massive, and its "year" -- the time it takes to orbit its star -- is only 11 days

• Its star is only 12 percent as massive as our sun and much dimmer (so its habitable zone, allowing liquid water on the surface, is much closer in) and the planet is 25 times closer in than Earth is to our sun

• The star may form a third part of the Alpha Centauri binary star system, separated by a distance of 15,000 "astronomical units," which could affect the planet's orbit and history

• The new data hint at the existence of a second planet in the system with an orbital period near 200 days, but this has not been proven

Perhaps the biggest obstacle to life on the planet, Barnes writes, is the brightness of its host star. Proxima Centauri, a red dwarf star, is comparatively dim, but wasn't always so.

"Proxima's brightness evolution has been slow and complicated," Barnes writes. "Stellar evolution models all predict that for the first one billion years Proxima slowly dimmed to its current brightness, which implies that for about the first quarter of a billion years, planet b's surface would have been too hot for Earth-like conditions."

Barnes notes that he and UW graduate student Rodrigo Luger recently showed that had modern Earth been in such a situation, "it would have become a Venus-like world, in a runaway greenhouse state that can destroy all of the planet's primordial water," thus extinguishing any chance for life.

Next come a host of questions about the planet's makeup, location and history, and the team's work toward discerning answers.

• Is the planet "rocky" like Earth? Most orbits simulated by the planetary lab suggest it could be -- and thus can host water in liquid form, a prerequisite for life

• Where did it form, and was there water? Whether it formed in place or farther from its star, where ice is more likely, VPL researchers believe it is "entirely possible" Proxima b could be water-rich, though they are not certain.

• Did it start out as a hydrogen-enveloped Neptune-like planet and then lose its hydrogen to become Earth-like? VPL research shows this is indeed possible, and could be a viable pathway to habitability

• Proxima Centauri flares more often than our sun; might such flares have long-since burned away atmospheric ozone that might protect the surface and any life? This is possible, though a strong magnetic field, as Earth has, could protect the surface.

Also, any life under even a few meters of liquid water would be protected from radiation.

Another concern is that the planet might be tidally locked, meaning one side permanently faces its star, as the moon does Earth. Astronomers long thought this to mean a world could not support life, but now believe planetwide atmospheric winds would transport heat around the planet.

"These questions are central to unlocking Proxima's potential habitability and determining if our nearest galactic neighbor is an inhospitable wasteland, an inhabited planet, or a future home for humanity," Barnes writes.

Planetary laboratory researchers also are developing techniques to determine whether Proxima b's atmosphere is amenable to life.

"Nearly all the components of an atmosphere imprint their presence in a spectrum (of light)," Barnes writes. "So with our knowledge of the possible histories of this planet, we can begin to develop instruments and plan observations that pinpoint the critical differences."

At high enough pressures, he notes, oxygen molecules can momentarily bind to each other to produce an observable feature in the light spectrum.

"Crucially, the pressures required to be detectable are large enough to discriminate between a planet with too much oxygen, and one with just the right amount for life.

As we learn more about the planet and the system, we can build a library of possible spectra from which to quantitatively determine how likely it is that life exists on planet b."

Our own sun is expected to burn out in about 4 billion years, but Proxima Centauri has a much better forecast, perhaps burning for 4 trillion years longer.

"If Proxima b is habitable, then it might be an ideal place to move. Perhaps we have just discovered a future home for humanity. But in order to know for sure, we must make more observations, run many more computer simulations and, hopefully, send probes to perform the first direct reconnaissance of an exoplanet," Barnes writes. "The challenges are huge, but Proxima b offers a bounty of possibilities that fills me with wonder."

Proxima Centauri b may be the first exoplanet to be directly characterized by powerful ground- and space-based telescopes planned for the future, and its atmosphere spectroscopically probed for active biology. The research was funded by the NASA Astrobiology Institute. "Whether habitable or not," Barnes concludes, "Proxima Centauri b offers a new glimpse into how the planets and life fit into our universe."

Author: Peter Kelley | Source: University of Washington [August 30, 2016]

An international team of scientists led by the University of Leicester has discovered a new species of fossil in England -- and identified it as an ancient parasitic intruder.

The fossil species found in 425-million year old rocks in Herefordshire, in the Welsh borderland, is described as 'exceptionally well preserved.' The specimens range from about 1 to 4 millimeters long.

The fossil species -- a 'tongue worm', which has a worm-like body and a head and two pairs of limbs -- is actually a parasite whose representatives today live internally in the respiratory system of a host, which it enters when it is eaten.

The new fossil, which was originally entirely soft-bodied, is the first fossil tongue worm species to be found associated with its host, which in this case is a species of ostracod -- a group of micro-arthropods (crabs, spiders and insects are also arthropods) with two shells that are joined at a hinge.

Professor David Siveter, of the Department of Geology at the University of Leicester made the discovery working alongside researchers from the Universities of Oxford, Imperial College London and Yale, USA. Their research is published in the journal Current Biology and was supported by The Natural Environmental Research Council, together with the Leverhulme Trust, the John Fell Oxford University Press (OUP) Research Fund and Yale Peabody Museum of Natural History.

Professor Siveter said: "This discovery is important not only because examples of parasites are exceptionally rare in the fossil record, but also because the possible host of fossil tongue worms -- and the origin of the lifestyle of tongue worms -- has been the subject of much debate.

"This discovery affirms that tongue worms were 'external' parasites on marine invertebrate animals at least 425 million years ago; it also suggests that tongue worms likely found their way into land-based environments and associated hosts in parallel with the movement of vertebrates onto the land by some 125 million years later."

Professor Siveter said tongue worms -- technically termed pentastomids -- are in fact not worms at all; they are an unusual group of tiny and widespread parasitic arthropods. Their fossils are exceptionally rare and until now are known only from a handful of isolated juvenile specimens.

Today they are known from about 140 species, nearly all of which are parasitic on vertebrate animals, particularly reptiles and including humans. Some of the fossil tongue worm specimens occur inside the shell, near the eggs of the ostracod; others are attached to the external surface of its shell, a unique position for any fossil or living tongue worm.

Professor Siveter added: "The tongue worm and its host lived in a sea that 425 million years ago -- during the Silurian period of geological time -- covered much of southern Britain, which was positioned then in warm southerly subtropical latitudes. The animals died and were preserved when a volcanic ash rained down upon them. The new species has been named Invavita piratica, which means an 'ancient intruder' and 'piracy', referring to its parasitic lifestyle in the sea."

The fossils have been reconstructed as virtual fossils by 3D computer modelling.

Source: University of Leicester [May 21, 2015]

The appearance of infectious diseases in new places and new hosts, such as West Nile virus and Ebola, is a predictable result of climate change, says a noted zoologist affiliated with the Harold W. Manter Laboratory of Parasitology at the University of Nebraska-Lincoln.

In an article published online today in conjunction with a special issue of the Philosophical Transactions of the Royal Society B, Daniel Brooks warns that humans can expect more such illnesses to emerge in the future, as climate change shifts habitats and brings wildlife, crops, livestock, and humans into contact with pathogens to which they are susceptible but to which they have never been exposed before.

"It's not that there's going to be one 'Andromeda Strain' that will wipe everybody out on the planet," Brooks said, referring to the 1971 science fiction film about a deadly pathogen. "There are going to be a lot of localized outbreaks putting pressure on medical and veterinary health systems. It will be the death of a thousand cuts."

Brooks and his co-author, Eric Hoberg, a zoologist with the U.S. National Parasite Collection of the USDA's Agricultural Research Service, have personally observed how climate change has affected very different ecosystems. During his career, Brooks has focused primarily on parasites in the tropics, while Hoberg has worked primarily in Arctic regions.

Each has observed the arrival of species that hadn't previously lived in that area and the departure of others, Brooks said.

"Over the last 30 years, the places we've been working have been heavily impacted by climate change," Brooks said in an interview last week. "Even though I was in the tropics and he was in the Arctic, we could see something was happening." Changes in habitat mean animals are exposed to new parasites and pathogens.

For example, Brooks said, after humans hunted capuchin and spider monkeys out of existence in some regions of Costa Rica, their parasites immediately switched to howler monkeys, where they persist today. Some lungworms in recent years have moved northward and shifted hosts from caribou to muskoxen in the Canadian Arctic.

But for more than 100 years, scientists have assumed parasites don't quickly jump from one species to another because of the way parasites and hosts co-evolve.

Brooks calls it the "parasite paradox." Over time, hosts and pathogens become more tightly adapted to one another. According to previous theories, this should make emerging diseases rare, because they have to wait for the right random mutation to occur.

However, such jumps happen more quickly than anticipated. Even pathogens that are highly adapted to one host are able to shift to new ones under the right circumstances.

Brooks and Hoberg call for a "fundamental conceptual shift" recognizing that pathogens retain ancestral genetic capabilities allowing them to acquire new hosts quickly.

"Even though a parasite might have a very specialized relationship with one particular host in one particular place, there are other hosts that may be as susceptible," Brooks said.

In fact, the new hosts are more susceptible to infection and get sicker from it, Brooks said, because they haven't yet developed resistance.

Though resistance can evolve fairly rapidly, this only changes the emergent pathogen from an acute to a chronic disease problem, Brooks adds.

"West Nile Virus is a good example - no longer an acute problem for humans or wildlife in North America, it nonetheless is hhere to stay," he said.

The answer, Brooks said, is for greater collaboration between the public and veterinary health communities and the "museum" community - the biologists who study and classify life forms and how they evolve.

In addition to treating human cases of an emerging disease and developing a vaccine for it, he said, scientists need to learn which non-human species carry the pathogen.

Knowing the geographic distribution and the behavior of the non-human reservoirs of the pathogen could lead to public health strategies based on reducing risk of infection by minimizing human contact with infected animals, much likethose that reduced the incidence of malaria and yellow fever by reducing human contact with mosquitos.

Museum scientists versed in understanding the evolutionary relationships among species could use this knowledge to anticipate the risk of the pathogen becoming established outside of its native range.

Brooks, who earned his bachelor's and master's degrees from the University of Nebraska-Lincoln, was a zoology professor at the University of Toronto for 30 years until he retired early in 2011 to devote more time to his study of emerging infectious disease. In addition to being a senior research fellow with UNL's Manter Laboratory, he is a visiting senior fellow at the Universidade Federal do Parana, Brazil, funded by the Ciencias sem Fronteiras (Sciences without Borders) of the Brazilian government, and a visiting scholar with Debrecen University in Hungary.

Brooks' and Hoberg's article, "Evolution in action: climate change, biodiversity dynamics and emerging infectious disease," is part of a Philosophical Transactions of the Royal Society B issue on "Climate change and vector-borne diseases of humans," edited by Paul Parham, a specialist in infectious disease epidemiology at Imperial College in London.

"We have to admit we're not winning the war against emerging diseases," Brooks said. "We're not anticipating them. We're not paying attention to their basic biology, where they might come from and the potential for new pathogens to be introduced."

Source: University of Nebraska-Lincoln [February 16, 2015]

Some of the UK's leading nature experts have delivered a clarion call for action to help save many of the nation's native wildlife species from extinction.

A critical new report, called >State of Nature 2016 and published, delivered the clearest picture to date of the status of our native species across land and sea. Crucially, the report attributes much of the imposing threat to changing agricultural land management, climate change and sustained urban development. These threaten many of Britain's best loved species including water voles -- the fastest declining mammal.

The startling report reveals that more than half (56%) of UK species studied have declined since 1970, while more than one in ten (1,199 species) of the nearly 8000 species assessed in the UK are under threat of disappearing altogether.

The report, produced by a coalition of more than 50 leading wildlife and research organisations and specialists including Dr Fiona Mathews from the University of Exeter, demands immediate action to stave off the growing threat to Britain's unique wildlife.

Dr Mathews, an Associate Professor in Mammalian Biology at the University of Exeter and Chair of the Mammal Society, who helped write the report, said many British mammals are under pressure from house building and intensification of agriculture.

She said: "The reality is that our human population is expanding and we need urgently to work out how we can live alongside our wildlife. For example, water voles are one of our fastest declining species, and many thousands of kilometres of their habitat are affected by development every year.

"We are therefore researching ways to ensure their survival, supported by our water vole appeal fund. In the summer, we launched best-practice guidance on looking after water voles during development, and these are now being followed by industry, helping to ensure that "Ratty" survives on ponds, rivers and canals throughout the UK."

As the UK Government and devolved administrations move forward in the light of the EU Referendum result, there is an opportunity to secure world leading protection for our species and restoration of our nature. Now is the time to make ambitious decisions and significant investment in nature to ensure year-on-year improvement to the health and protection of the UK's nature and environment for future generations. The Mammal Society is currently drawing up a 'Red List' of the most threated species, to help ensure that scarce funds are directed to the animals most in need.

Dr Mathews added: "The findings emphasise that whole ecosystems, not just one or two species, are under threat.

"We are a nation of nature-lovers -- just look at the success of "Countryfile" and "Springwatch." Every week thousands of volunteers are out recording wildlife and helping with practical habitat management. We also depend on the natural environment for a huge number of goods and services, not to mention our own health and wellbeing.

"Yet successive governments have cut funding for the environment, and conservation concerns are all too often vilified as a barrier to urban development, infrastructure projects or efficient food production. This is a moment to reflect on what sort of country we want for our children -- a sustainable future for them depends on our decisions now."

The State of Nature 2016 UK report will be launched by Sir David Attenborough and UK conservation and research organisations at the Royal Society in London on Wednesday, September 14, while separate events will be held in Edinburgh, Cardiff and Belfast over the next week.

Sir David Attenborough said: "The natural world is in serious trouble and it needs our help as never before. The rallying call issued after the State of Nature report in 2013 has promoted exciting and innovative conservation projects. Landscapes are being restored, special places defended, struggling species being saved and brought back. But we need to build significantly on this progress if we are to provide a bright future for nature and for people.

"The future of nature is under threat and we must work together -- -Governments, conservationists, businesses and individuals -- -to help it. Millions of people in the UK care very passionately about nature and the environment and I believe that we can work together to turn around the fortunes of wildlife."

In order to reduce the impact we are having on our wildlife, and to help struggling species, we needed to understand what's causing these declines. Using evidence from the last 50 years, experts have identified that significant and ongoing changes in agricultural practices are having the single biggest impact on nature.

The widespread decline of nature in the UK remains a serious problem to this day. For the first time scientists have uncovered how wildlife has fared in recent years. The report reveals that since 2002 more than half (53%) of UK species studied have declined and there is little evidence to suggest that the rate of loss is slowing down.

Mark Eaton, lead author on the report, said:"Never before have we known this much about the state of UK nature and the threats it is facing. Since the 2013, the partnership and many landowners have used this knowledge to underpin some amazing scientific and conservation work. But more is needed to put nature back where it belongs -- we must continue to work to help restore our land and sea for wildlife.

"There is a real opportunity for the UK Government and devolved administrations to build on these efforts and deliver the significant investment and ambitious action needed to bring nature back from the brink.

"Of course, this report wouldn't have been possible without the army of dedicated volunteers who brave all conditions to survey the UK's wildlife. Knowledge is the most essential tool that a conservationist can have, and without their efforts, our knowledge would be significantly poorer."

Derek Crawley, Atlas Office for the Mammal Society, said "New technology now enables volunteers to share information more easily than ever before. Our MammalTracker app is freely available from the App Store, or sightings of mammals can be recorded via our website. We will also be sharing information on how to make the most of volunteer programmes at a special meeting in the autumn.

Source: University of Exeter [September 23, 2016]

Gaps in our information about biodiversity means we are at risk of focussing our conservation efforts in the wrong places.

New research from Newcastle University, UK, University College London (UCL) and the University of Queensland, Australia, highlights the uncertainty around our global biodiversity data because of the way we record species sightings.

The study explains how a lack of information about a species in a particular location doesn't necessarily mean it's not there and that recording when we don't see something is as important as recording when we do.

Changing the way we record data

Publishing their findings in the journal Biology Letters, the team say we need to change the way we record sightings -- or a lack of them -- so we can better prioritise our conservation efforts in light of the Convention on Biological Diversity.

Dr Phil McGowan, one of the study's authors and a Senior Lecturer in Biodiversity and Conservation at Newcastle University, said: "Where there is no recent biodiversity data from an area then we might assume a species is no longer found there, but there could be a number of other possible reasons for this lack of data. It could be that its habitat is inaccessible -- either geographically or due to human activity such as ongoing conflict -- or perhaps it's simply a case that no-one has been looking for it. Unless we know where people have looked for a particular species and not found it then we can't be confident that it's not there."

Galliformes and man

To test the research, the team used the rigorously compiled database of European and Asian Galliformes -- a group of birds which includes the pheasant, grouse and quail.

"Our long-standing love of the Galliformes goes back hundreds of years which means we have records that are likely to be much better than for other groups of animals or plants," explains Dr McGowan.

"Not only have these birds been hunted for food, but their spectacular colours made them valuable as trophies and to stock the private aviaries of the wealthy. In the late 1800s and the turn of the last century, the Galliformes were prized specimens in museum and private collections and today they are still a favourite with bird watchers."

Data absent from 40% of the study area

Analysing 153,150 records dating from 1727 to 2008 and covering an area from the UK to Siberia and down to Indonesia, the team found that after 1980, there was no available data at 40% of the locations where Galliformes had previously been present.

The study suggests two possible scenarios.

Dr Elizabeth Boakes, the study's lead author and a teaching fellow at University College London, said: "We have no evidence of populations existing past 1980 in 40% of our locations. However, absence of evidence is not evidence of absence. One scenario is that populations have been lost from these areas, probably due to hunting or habitat loss. The other scenario is that the species are still locally present but that nobody has been to look for them. Our study shows that which scenario you choose to believe makes a huge difference to measures used in conservation priority-setting such as species richness and geographic range. It's important that we make the right call and that means a big shake up in the way we currently monitor biodiversity. We need to record what we don't see as well as what we do see and we need to be recording across much wider areas."

Meeting international targets

Involving 192 countries and the EU, the Convention on Biological Diversity is dedicated to promoting sustainable development.

The goals include the Strategic Plan for Biodiversity which says we must at least halve and, where feasible, bring close to zero the rate of loss of natural habitats, including forests, and halt extinction of those species we know to be under threat.

"In order to start meeting these goals we must first understand exactly which organisms are close to extinction and need prioritising in order to meet this target," explains Dr McGowan, who is Co-chair of IUCN Species Survival Commission's Policy Subcommittee and a member of its Strategic Conservation Planning Subcommittee.

"The IUCN Red List of Threatened Species is a good starting point but as our research shows, it's only as accurate as the data that's been collected. Going forward, we need to make sure we are recording when we've not seen something just as much as when we do and that's where keen and informed members of the public -- such as bird watching groups -- could really help us."

Source: Newcastle University [March 08, 2016]

Scientists from the University of Liverpool have developed computer models of the bodies of sauropod dinosaurs to examine the evolution of their body shape.

Sauropod dinosaurs include the largest land animals to have ever lived. Some of the more well-known sauropods include Diplodocus, Apatosaurus and Brontosaurus. They are renowned for their extremely long necks, long tails as well as four thick, pillar-like legs and small heads in relation to their body.

To date, however, there have been only limited attempts to examine how this unique body-plan evolved and how it might be related to their gigantic body size. Dr Karl Bates from the University's Department of Musculoskeletal Biology and his colleagues used three-dimensional computer models reconstructing the bodies of sauropod dinosaurs to analyse how their size, shape and weight-distribution evolved over time.

Evolutionary history

Dr Bates found evidence that changes in body shape coincided with major events in sauropod evolutionary history such as the rise of the titanosaurs. The early dinosaurs that sauropods evolved from were small and walked on two legs, with long tails, small chests and small forelimbs. The team estimate that this body shape concentrated their weight close to the hip joint, which would have helped them balance while walking bipedally on their hind legs.

As sauropods evolved they gradually altered both their size and shape from this ancestral template, becoming not only significantly larger and heavier, but also gaining a proportionally larger chest, forelimbs and in particular a dramatically larger neck.

>A Giraffatitan model of a Sauropod showing how the centre of mass is moved by> reconstructing the soft tissues differently using the convex hulling approach >[Credit: Dr Peter L Falkingham/Liverpool John Moores University]
The team's findings show that these changes altered sauropods' weight distribution as they grew in size, gradually shifting from being tail-heavy, two-legged animals to being front-heavy, four-legged animals, such as the large, fully quadrupedal Jurassic sauropods Diplodocus and Apatosaurus.

The team found that these linked trends in size, body shape and weight distribution did not end with the evolution of fully quadrupedal sauropods. In the Cretaceous period - the last of the three ages of the dinosaurs - many earlier sauropod groups dwindled. In their place, a new and extremely large type of sauropod known as titanosaurs evolved, including the truly massive Argentinosaurus and Dreadnoughtus, among the largest known animals ever to have lived.

Front heavy

The team's computer models suggest that in addition to their size, the titanosaurs evolved the most extreme 'front heavy' body shape of all sauropods, as a result of their extremely long necks.

Dr Bates said: "As a result of devising these models we were able to ascertain that the relative size of sauropods' necks increased gradually over time, leading to animals that were increasingly more front-heavy relative to their ancestors."

Dr Philip Mannion from Imperial College London, a collaborator in the research, added: "These innovations in body shape might have been key to the success of titanosaurs, which were the only sauropod dinosaurs to survive until the end-Cretaceous mass extinction, 66 million years ago."

Dr Vivian Allen from the Royal Veterinary College London, who also collaborated in the research, added: "What's important to remember about studies like this is that there is a very high degree of uncertainty about exactly how these animals were put together. While we have good skeletons for many of them, it's difficult to be sure how much meat there was around each of the bones. We have built this uncertainly into our models, ranging each body part from emaciated to borderline obesity, and even using these extremes we still find these solid, trending changes in body proportions over sauropod evolution."

The paper has been published by the Royal Society Open Science journal.

Source: University of Liverpool [March 29, 2016]

When members of the BaYaka Pygmies living in the northern Republic of Congo get sick, they don't just go to the doctor for a prescription. Instead, they rely on their shared knowledge of medicinal plants to help them get well. Now, researchers reporting in the Cell Press >journal Current Biology on September 8 have examined shared uses of those plants to understand how Pygmies have passed their extensive plant knowledge along from one person to the next.

The findings show the important role of marital bonds in passing information to otherwise distant families. There were some surprises, too.

"I wasn't expecting that plant uses would be so diverse," says Gul Deniz Salali (@DenizSalali) of University College London. She hadn't expected to find that plants would play an important role in executing social norms, either. "But many Pygmies told me that they used particular plants to detect and punish cheaters."

Salali was interested in exploring how hunter-gatherers accumulated the vast repertoire of plant uses that have helped them to survive in tropical rainforests. To find out, she and her colleagues examined the reported co-occurrence of plant uses between pairs of BaYaka Pygmy individuals based on extensively conducted interviews. Their study included reported uses of 33 different plants by 219 individuals living in four camps.

"We found that long-term pair bonds between men and women allowed otherwise distant families to combine information on medicinal uses of plants," Salali says. "Living in multi-family camps, on the other hand, enabled Pygmies to exchange and accumulate plant knowledge related to cooperative foraging and social beliefs."

The most commonly reported medicinal uses of plants were for treating digestive and respiratory disorders. The BaYaka also use some plants for collecting caterpillars or honey and as a poison for killing monkeys or fish. Other plants were used to regulate social life, including matters concerning lying or sexual taboos.

As an example, Salali says, some Pygmies use the juice extracted from a particular type of tree bark to detect and punish cheaters. "If someone cheated their partner, camp members would squeeze the poisonous juice into the person's eyes which could affect his or her vision. If his or her vision was affected, then people thought the person was guilty. I found that the knowledge on this type of plant use was widely shared among the campmates."

Knowledge of medicinal plants is mainly shared between spouses and other relatives, they found. But plant uses associated with foraging and social norms were often shared more widely among campmates, regardless of relatedness, playing an important role in camp-wide activities that require cooperation.

The researchers also found that BaYaka mothers who used more plants for treating certain diseases had healthier children.

Salali says her next step is to compare plant knowledge and use in hunter-gatherers living in varying proximity to market towns in Congo. "I have lived in some Pygmy camps that were located in the forest, and some larger ones that were located in a logging town," she says. "I am interested in exploring the biological and cultural adaptations of groups in transition from a nomadic hunter-gatherer lifestyle to a more sedentary farming way of life."

Source: Cell Press [September 08, 2016]

From skeletal remains found among ancient owl pellets, a team of scientists has recovered the first ancient DNA of the extinct West Indian mammal Nesophontes, meaning "island murder." They traced its evolutionary history back to the dawn of mammals 70 million years ago.

The authors, including Selina Brace, Jessica Thomas, Ian Barnes et al., published their findings in the advanced online edition of >Molecular Biology and Evolution.

The insect-eating creature existed in the Caribbean islands until the 16th century when, perhaps, they were outcompeted as the first Spanish ships arrived—-introducing rats as stowaways. "Nesophontes was just one of the dozens of mammals that went extinct in the Caribbean during recent times," said Professor Ian Barnes, Research Leader at London's Natural History Museum.

Scientists used a 750-year-old specimen to generate many thousands of base pairs of DNA sequence data. This allowed the research team to uncover its evolutionary origins and finally resolve the relationships between its closest relatives, the insectivores, a group including shrews, hedgehogs and moles. Phylogenetic and divergence time scenarios clearly demonstrate that Nesophontes is a deeply distinct sister group to another group of living native Caribbean insectivores, the solenodons. The time of the split between these two correlates with an era when the northern Caribbean was formed of volcanic islands, well before the origins of the islands we see today.

Obtaining DNA from tropical fossils is notoriously difficult, and the team made use of the latest developments in ancient DNA technology to conduct the study.

"Once we'd dealt with the tiny size of the bone samples, the highly degraded state of the DNA, and the lack of any similar genomes to compare to, the analysis was a piece of cake," said Natural History Museum scientist Dr. Selina Brace.

The findings will be of considerable interest for evolutionary biologists studying mammalian biogeography, and the significant role that humans may have played in a recent extinction.

Source: Oxford University Press [September 13, 2016]

New research suggests that the dodo, an extinct bird whose name has entered popular culture as a symbol of stupidity, was actually fairly smart. The work, published in the Zoological Journal of the Linnean Society, finds that the overall size of the dodo's brain in relation to its body size was on par with its closest living relatives: pigeons--birds whose ability to be trained implies a moderate level of intelligence. The researchers also discovered that the dodo had an enlarged olfactory bulb -- the part of the brain responsible for smelling -- an uncharacteristic trait for birds, which usually concentrate their brainpower into eyesight.

The dodo (Raphus cucullatus) was a large, flightless bird that lived on the island of Mauritius in the Indian Ocean. They were last seen in 1662.

"When the island was discovered in the late 1500s, the dodos living there had no fear of humans and they were herded onto boats and used as fresh meat for sailors," said Eugenia Gold, the lead author of the paper, a research associate and recent graduate of the American Museum of Natural History's Richard Gilder Graduate School, and an instructor in the Department of Anatomical Sciences at Stony Brook University. "Because of that behavior and invasive species that were introduced to the island, they disappeared in less than 100 years after humans arrived. Today, they are almost exclusively known for becoming extinct, and I think that's why we've given them this reputation of being dumb."

Even though the birds have become an example of oddity, obsolescence, stupidity, and extinction, and have been featured in popular stories ranging from Alice in Wonderland to Ice Age, most aspects of the dodo's biology are still unknown. This is partly because dodo specimens are extremely rare, having disappeared during the nascent stage of natural history collections.

To examine the brain of the dodo, Gold tracked down a well-preserved skull from the collections of the Natural History Museum, London, and imaged it there with high-resolution computed tomography (CT) scanning. In the American Museum of Natural History's Microscopy and Imaging Facility, she also CT-scanned the skulls of seven species of pigeons -- ranging from the common pigeon found on city streets, Columba livia, to more exotic varieties. Out of these scans, Gold built virtual brain endocasts to determine the overall brain size as well as the size of various structures. Gold's colleagues at the Natural History Museum of Denmark and National Museum of Scotland sent her the endocast for the dodo's closest relative, the extinct island-dwelling bird Rodrigues solitaire (Pezophaps solitaria).

When comparing the size of the birds' brains to their body sizes, Gold and collaborators found that the dodo was "right on the line."

"It's not impressively large or impressively small -- it's exactly the size you would predict it to be for its body size," Gold said. "So if you take brain size as a proxy for intelligence, dodos probably had a similar intelligence level to pigeons. Of course, there's more to intelligence than just overall brain size, but this gives us a basic measure."

The study also revealed that both the dodo and the Rodrigues solitaire, which recently was driven to extinction by human activity, had large and differentiated olfactory bulbs. In general, birds depend much more on sight rather than smell to navigate through their world, and as a result, they tend to have larger optic lobes than olfactory bulbs. The authors suggest that, because dodos and solitaires were ground-dwellers, they relied on smell to find food, which might have included fruit, small land vertebrates, and marine animals like shellfish.

"It is really amazing what new technologies can bring to old museum specimens," said co-author Mark Norell, Macaulay Curator of Paleontology and Chair of the Division of Paleontology at the American Museum of Natural History. "This really underscores the need for the maintenance and growth of natural history collections, because who knows what's next."

The researchers also discovered an unusual curvature of the dodo's semicircular canal -- the balance organs located in the ear. But as of yet, there's not a good hypothesis for this atypical feature.

Source: American Museum of Natural History [February 23, 2016]

Mammals immortalise their genes through eggs and sperm to ensure future generations inherit good quality mitochondria to power the body's cells, according to new UCL research.

Before now, it was not known why mammals rely on dedicated sex cells that are formed early in development (a germline) to make offspring whereas plants and other simple animals, such as corals and sponges, use sex cells produced later in life from normal body tissues.

In a new study, published today in >PLOS Biology and funded by Natural Environment Research Council, Engineering & Physical Sciences Research Council and the Leverhulme Trust, UCL scientists developed an evolutionary model to investigate how these differences evolved over time and discovered that the germline in mammals developed in response to selection on mitochondria (the powerhouses of cells).

First author and UCL PhD student, Arunas Radzvilavicius, said: "There have been many theories about why mammals have a specialised germline when plants and other ancient animals don't. Some suggest it was due to complexity of tissues or a selfish conflict between cells. The distinction between sex cells and normal body tissues seems to be necessary for the evolution of very complex specialised tissues like brain.

"Surprisingly, we found that these aren't the reason. Rather, it's about the number of genetic mutations in mitochondrial DNA over time, which differs between organisms, and the variation between cells caused by the mitochondria being randomly partitioned into daughter cells at each division."

In plants, mitochondrial mutations creep in slowly, so a germline isn't needed as mutations are corrected by natural selection. Mitochondrial variation is maximised by forming the next generation from the same cells used to make normal tissue cells. When the cells divide to form new daughter cells, some receive more mutant mitochondria than others and these cells are then removed through natural selection, preserving the reproductive cells containing higher quality mitochondria.

In mammals, genetic errors in mitochondria accumulate more quickly due to our higher metabolic rate so using cells that have undergone lots of division cycles would be a liability. Mitochondria are therefore only passed along to the next generation through a dedicated female germline in the form of large eggs. This protects against errors being introduced as eggs undergo many fewer replication cycles than cells in other tissues such as the gut, skin and blood.

The germline ensures that the best quality mitochondria are transferred but restricts the genetic variation in the next generation of cells in the developing embryo. This is corrected for by mammals generating far too many egg cells which are removed during development. For example, humans are born with over 6 million egg-precursor cells, 90% of which are culled by the start of puberty in a mysterious process called atresia.

Senior author, Dr Nick Lane (UCL CoMPLEX and Genetics, Evolution & Environment) added: "We think the rise in mitochondrial mutation rate likely occurred in the Cambrian explosion 550 million years ago when oxygen levels rose. This was the first appearance of motile animals in the fossil record, things like trilobites that had eyes and armour plating - predators and prey. By moving around they used their mitochondria more and that increased the mutation rate. So to avoid these mutations accumulating they needed to have fewer rounds of cell division, and that meant sequestering a specialized germline."

Co-author, Professor Andrew Pomiankowski (UCL Genetics, Evolution & Environment), concluded: "Without a germline, animals with complex development and brains could not exist. Scientists have long tried to explain the evolution of the germline in terms of complexity. Who would have thought it arose from selection on mitochondrial genes? We hope our discovery will transform the way researchers understand animal development, reproduction and aging."

Source: University College London [December 20, 2016]

Genes that drive the shape of human noses have been identified by a UCL-led study. The four genes mainly affect the width and 'pointiness' of noses which vary greatly between different populations. The new information adds to our understanding of how the human face evolved and may help contribute to forensic DNA technologies that build visual profiles based on an individual's genetic makeup.

The study, published today in >Nature Communications, analysed a population of over 6,000 people with varied ancestry across Latin America to study the differences in normal facial features and identify the genes which control the shape of the nose and chin.

The researchers identified five genes which play a role in controlling the shape of specific facial features. DCHS2, RUNX2, GLI3 and PAX1 affect the width and pointiness of the nose and another gene -- EDAR -- affects chin protrusion.

"Few studies have looked at how normal facial features develop and those that have only looked at European populations, which show less diversity than the group we studied. What we've found are specific genes which influence the shape and size of individual features, which hasn't been seen before.

"Finding out the role each gene plays helps us to piece together the evolutionary path from Neanderthal to modern humans. It brings us closer to understanding how genes influence the way we look, which is important for forensics applications," said the first author of the report, Dr Kaustubh Adhikari, UCL Cell & Developmental Biology.

People have different shaped facial features based on their genetic heritage and this is partly due to how the environment influenced the evolution of the human genome. The nose, for example, is important for regulating the temperature and humidity of the air we breathe in so developed different shapes in warmer and cooler climates.

"It has long been speculated that the shape of the nose reflects the environment in which humans evolved. For example, the comparatively narrower nose of Europeans has been proposed to represent an adaptation to a cold, dry climate. Identifying genes affecting nose shape provides us with new tools to examine this question, as well as the evolution of the face in other species. It may also help us understand what goes wrong in genetic disorders involving facial abnormalities," explained Professor Andrés Ruiz-Linares UCL Biosciences, who led the study.

The team collected and analysed DNA samples from 6,630 volunteers from the CANDELA cohort recruited in Brazil, Colombia, Chile, Mexico and Peru. After an initial screen, a sample size of 5,958 was used. This group included individuals of mixed European (50%), Native American (45%) and African (5%) ancestry, resulting in a large variation in facial features.

Both men and women were assessed for 14 different facial features and whole genome analysis identified the genes driving differences in appearance.

A subgroup of 3,000 individuals had their features assessed using a 3D reconstruction of the face in order to obtain exact measurements of facial features and the results identified the same genes.

The study identified genes that are involved in bone and cartilage growth and the development of the face. GLI3, DCHS2 and PAX1 are all genes known to drive cartilage growth -- GLI3 gave the strongest signal for controlling the breadth of nostrils, DCHS2 was found to control nose 'pointiness' and PAX1 also influences nostril breadth. RUNX2 which drives bone growth was seen to control nose bridge width.

The genes GLI3, DCHS2 and RUNX2 are known to show strong signals of recent selection in modern humans compared to archaic humans such as Neanderthals and Denisovans; GLI3 in particular undergoing rapid evolution.

Source: University College London [May 19, 2016]