The Great London [Search results for Evolution] 

Extra-terrestrials that resemble humans should have evolved on other, Earth-like planets, making it increasingly paradoxical that we still appear to be alone in the universe, the author of a new study on convergent evolution has claimed.

The argument is one of several that emerge from The Runes Of Evolution, a new book in which the leading evolutionary biologist, Professor Simon Conway Morris, makes the case for a ubiquitous "map of life" that governs the way in which all living things develop.

It builds on the established principle of convergent evolution, a widely-supported theory -- although one still disputed by some biologists -- that different species will independently evolve similar features.

Conway Morris argues that convergence is not just common, but everywhere, and that it has governed every aspect of life's development on Earth. Proteins, eyes, limbs, intelligence, tool-making -- even our capacity to experience orgasms -- are, he argues, inevitable once life emerges.

The book claims that evolution is therefore far from random, but a predictable process that operates according to a fairly rigid set of rules.

If that is the case, then it follows that life similar to that on Earth would also develop in the right conditions on other, equivalent planets. Given the growing number of Earth-like planets of which astronomers are now aware, it is increasingly extraordinary that aliens that look and behave something like us have not been found, he suggests.

"Convergence is one of the best arguments for Darwinian adaptation, but its sheer ubiquity has not been appreciated," Professor Conway Morris, who is a Fellow at St John's College, University of Cambridge, said.

"Often, research into convergence is accompanied by exclamations of surprise, describing it as uncanny, remarkable and astonishing. In fact it is everywhere, and that is a remarkable indication that evolution is far from a random process. And if the outcomes of evolution are at least broadly predictable, then what applies on Earth will apply across the Milky Way, and beyond."

Professor Conway Morris has previously raised the prospect that alien life, if out there, would resemble earthlings -- with limbs, heads, and bodies -- notably at a Royal Society Conference in London in 2010. His new book goes even further, however, adding that any Earth-like planet should also evolve thunniform predators (like sharks), pitcher plants, mangroves, and mushrooms, among many other things.

Limbs, brains and intelligence would, similarly, be "almost guaranteed." The traits of human-like intelligence have evolved in other species -- the octopus and some birds, for example, both exhibit social playfulness -- and this, the book suggests, indicates that intelligence is an inevitable consequence of evolution that would characterise extraterrestrials as well.

Underpinning this is Conway Morris' claim that convergence is demonstrable at every major stepping stone in evolutionary history, from early cells, through to the emergence of tissues, sensory systems, limbs, and the ability to make and use tools.

The theory, in essence, is that different species will evolve similar solutions to problems via different paths. A commonly-cited example is the octopus, which has evolved a camera eye that is closely similar to that of humans, although distinctive in important ways that reflect its own history. Although octopi and humans have a common ancestor, possibly a slug-like creature, this lived 550 million years ago and lacked numerous complex features that the two now share. The camera eye of each must therefore have evolved independently.

Conway Morris argues that this process provides an underlying evolutionary framework that defines all life, and leads to innumerable surprises in the natural world. The book cites examples such as collagen, the protein found in connective tissue, which has emerged independently in both fungi and bacteria; or the fact that fruit flies seem to get drunk in the same manner as humans. So too the capacity for disgust in humans -- a hard-wired instinct helping us avoid infection and disease -- is also exhibited by leaf-cutter ants.

The study also identifies many less obvious evolutionary "analogues," where species have evolved certain properties and characteristics that do not appear to be alike, but are actually very similar. For example, "woodpeckerlike habits" are seen in lemurs and extinct marsupials, while the mechanics of an octopus' tentacles are far closer to those of a human arm than we might expect, and even their suckers can operate rather like hands.

Conway Morris contends that all life navigates across this evolutionary map, the basis of what he describes as a "predictive biology." "Biology travels through history," he writes, "but ends up at much the same destination."

This, however, raises fascinating and problematic questions about the possibility of life occurring on other planets. "The number of Earth-like planets seems to be far greater than was thought possible even a few years ago," Conway Morris said. "That doesn't necessarily mean that they have life, because we don't necessarily understand how life originates. The consensus offered by convergence, however, is that life is going to evolve wherever it can."

"I would argue that in any habitable zone that doesn't boil or freeze, intelligent life is going to emerge, because intelligence is convergent. One can say with reasonable confidence that the likelihood of something analogous to a human evolving is really pretty high. And given the number of potential planets that we now have good reason to think exist, even if the dice only come up the right way every one in 100 throws, that still leads to a very large number of intelligences scattered around, that are likely to be similar to us."

If this is so, as the book suggests in its introduction, then it makes Enrico Fermi's famous paradox -- why, if aliens exist, we have not yet been contacted -- even more perplexing. "The almost-certainty of ET being out there means that something does not add up, and badly," Conway Morris said. "We should not be alone, but we are."

The Runes Of Evolution was six years in the making and draws on thousands of academic sources, and throws up numerous other, surprising findings as well. Sabre-teeth, for example, turn out to be convergent, and Conway Morris explains why it is that the clouded leopard of Asia, Neofelis nebulosa, has developed features that could, as it evolves "presage the emergence of a new sabre-tooth," although sadly it looks set to become extinct before this happens. Elsewhere, the study suggests that certain prehistoric creatures other than bats and birds may have attempted to evolve flight.

"It makes people slightly uneasy that evolution can end up reaching the same solutions to questions about how to catch something, how to digest something, and how to work," Conway Morris added. "But while the number of possibilities in evolution in principle is more than astronomical, the number that actually work is an infinitesimally smaller fraction."

The Runes Of Evolution, by Simon Conway Morris, is published by Templeton Press

Source: University of Cambridge [July 02, 2015]

Our ancestors evolved three times faster in the 10 million years after the extinction of the dinosaurs than in the previous 80 million years, according to UCL researchers.

The team found the speed of evolution of placental mammals -- a group that today includes nearly 5000 species including humans -- was constant before the extinction event but exploded after, resulting in the varied groups of mammals we see today.

Lead researcher, Dr Thomas Halliday (UCL Genetics, Evolution & Environment), said: "Our ancestors -- the early placental mammals - benefitted from the extinction of non-avian dinosaurs and dwindling numbers of competing groups of mammals. Once the pressure was off, placental mammals suddenly evolved rapidly into new forms.

"In particular, we found a group called Laurasiatheria quickly increased their body size and ecological diversity, setting them on a path that would result in a modern group containing mammals as diverse as bats, cats, rhinos, whales, cows, pangolins, shrews and hedgehogs."

The team found that the last common ancestor for all placental mammals lived in the late Cretaceous period, about three million years before the non-avian dinosaurs became extinct 66 million years ago. This date is 20 million years younger than suggestions from previous studies which used molecular data from living mammals and assumed a near-constant rate of evolution.

In this study, funded by the Natural Environment Research Council and published in >Proceedings B of the Royal Society, the researchers analysed fossils from the Cretaceous to the present day, and used the dates of their occurrence in the fossil record to estimate the timing of divergences based on an updated tree of life. The new tree was released by the same team in 2015 and has the largest representation of Paleocene mammals to date.

The scientists measured all the small changes in the bones and teeth of 904 placental fossils and mapped the anatomical differences between species on the tree of life. From measuring the number of character changes over time for each branch, they found the average rate of evolution for early placental mammals both before and after the dinosaur extinction event. They compared the average rate of evolution over the geological stages before the extinction and the geological stages after to see what impact it had.

Senior author, Professor Anjali Goswami (UCL Genetics, Evolution & Environment and UCL Earth Sciences), said: "Our findings refute those of other studies which overlooked the fossils of placental mammals present around the last mass extinction. Using rigorous methods, we've successfully tracked the evolution of early placental mammals and reconstructed how it changed over time. While the rate differed between species, we see a clear and massive spike in the rates of evolution straight after the dinosaurs become extinct, suggesting our ancestors greatly benefitted from the demise of the dinosaurs. The huge impact of the dinosaur extinction on the evolution of our ancestors really shows how important this event was in shaping the modern world."

Professor Paul Upchurch (UCL Earth Sciences), co-author of the study, added: "Our large and refined data set allows us to build a clearer picture of evolutionary history. We plan on using it to study other large-scale evolutionary patterns such as how early placental mammals dispersed across the continents via land bridges that no longer exist today."

Source: University College London [June 28, 2016]

Species across the world are rapidly going extinct due to human activities, but humans are also causing rapid evolution and the emergence of new species. A new study published today summarises the causes of humanmade speciation, and discusses why newly evolved species cannot simply replace extinct wild species. The study was led by the Center for Macroecology, Evolution and Climate at the University of Copenhagen.

A growing number of examples show that humans not only contribute to the extinction of species but also drive evolution, and in some cases the emergence of entirely new species. This can take place through mechanisms such as accidental introductions, domestication of animals and crops, unnatural selection due to hunting, or the emergence of novel ecosystems such as the urban environment.

Although tempting to conclude that human activities thus benefit as well as deplete global biodiversity, the authors stress that extinct wild species cannot simply be replaced with newly evolved ones, and that nature conservation remains just as urgent.

"The prospect of 'artificially' gaining novel species through human activities is unlikely to elicit the feeling that it can offset losses of 'natural' species. Indeed, many people might find the prospect of an artificially biodiverse world just as daunting as an artificially impoverished one" says lead author and Postdoc Joseph Bull from the Center for Macroecology, Evolution and Climate at the University of Copenhagen.

The study which was carried out in collaboration with the University of Queensland was published in >Proceedings of Royal Society B. It highlights numerous examples of how human activities influence species' evolution. For instance: as the common house mosquito adapted to the environment of the underground railway system in London, it established a subterranean population. Now named the 'London Underground mosquito', it can no longer interbreed with its above ground counterpart and is effectively thought to be a new species.

"We also see examples of domestication resulting in new species. According to a recent study, at least six of the world's 40 most important agricultural crops are considered entirely new" explains Joseph Bull.

Furthermore, unnatural selection due to hunting can lead to new traits emerging in animals, which can eventually lead to new species, and deliberate or accidental relocation of species can lead to hybridization with other species. Due to the latter, more new plant species in Europe have appeared than are documented to have gone extinct over the last three centuries.

Although it is not possible to quantify exactly how many speciation events have been caused through human activities, the impact is potentially considerable, the study states.

"In this context, 'number of species' becomes a deeply unsatisfactory measure of conservation trends, because it does not reflect many important aspects of biodiversity. Achieving a neutral net outcome for species numbers cannot be considered acceptable if weighing wild fauna against relatively homogenous domesticated species. However, considering speciation alongside extinction may well prove important in developing a better understanding of our impact upon global biodiversity. We call for a discussion about what we, as a society, actually want to conserve about nature" says Associate Professor Martine Maron from the University of Queensland.

Researchers do agree that current extinction rates may soon lead to a 6th period of mass extinction. Since the last Ice Age, 11.500 years ago, it is estimated that 255 mammals and 523 bird species has gone extinct, often due to human activity. In the same period, humans have relocated almost 900 known species and domesticated more than 470 animals and close to 270 plant species.

Source: Faculty of Science - University of Copenhagen [June 28, 2016]

The diversity of mammals on Earth exploded straight after the dinosaur extinction event, according to UCL researchers. New analysis of the fossil record shows that placental mammals, the group that today includes nearly 5000 species including humans, became more varied in anatomy during the Paleocene epoch - the 10 million years immediately following the event.

Senior author, Dr Anjali Goswami (UCL Genetics, Evolution & Environment), said: "When dinosaurs went extinct, a lot of competitors and predators of mammals disappeared, meaning that a great deal of the pressure limiting what mammals could do ecologically was removed. They clearly took advantage of that opportunity, as we can see by their rapid increases in body size and ecological diversity. Mammals evolved a greater variety of forms in the first few million years after the dinosaurs went extinct than in the previous 160 million years of mammal evolution under the rule of dinosaurs."

The Natural Environment Research Council-funded research, published today in the Biological Journal of the Linnean Society, studied the early evolution of placental mammals, the group including elephants, sloths, cats, dolphins and humans. The scientists gained a deeper understanding of how the diversity of the mammals that roamed the Earth before and after the dinosaur extinction changed as a result of that event.

Placental mammal fossils from this period have been previously overlooked as they were hard to place in the mammal tree of life because they lack many features that help to classify the living groups of placental mammals. Through recent work by the same team at UCL, this issue was resolved by creating a new tree of life for placental mammals, including these early forms, which was described in a study published in Biological Reviews yesterday.

First author of both papers, Dr Thomas Halliday (UCL Earth Sciences and Genetics, Evolution & Environment), said: "The mass extinction that wiped out the dinosaurs 66 million years ago is traditionally acknowledged as the start of the 'Age of Mammals' because several types of mammal appear for the first time immediately afterwards.

"Many recent studies suggest that little changed in mammal evolution during the Paleocene but these analyses don't include fossils from that time. When we look at the mammals that were present, we find a burst of evolution into new forms, followed by specialisation that finally resulted in the groups of mammals we see today. The earliest placental mammal fossils appear only a few hundred thousand years after the mass extinction, suggesting the event played a key role in diversification of the mammal group to which we belong."

The team studied the bones and teeth of 904 placental fossils to measure the anatomical differences between species. This information was used to build an updated tree of life containing 177 species within Eutheria (the group of mammals including all species more closely related to us than to kangaroos) including 94 from the Paleocene - making it the tree with the largest representation from Paleocene mammals to date. The new tree was analysed in time sections from 140 million years ago to present day, revealing the change in the variety of species.

Three different methods were used by the team to investigate the range and variation of the mammals present and all showed an explosion in mammal diversity after the dinosaur extinction. This is consistent with theories that mammals flourished when dinosaurs were no longer hunting them or competing with them for resources.

Dr Anjali Goswami (UCL Genetics, Evolution & Environment), added: "Extinctions are obviously terrible for the groups that go extinct, non-avian dinosaurs in this case, but they can create great opportunities for the species that survive, such as placental mammals, and the descendants of dinosaurs: birds."

Professor Paul Upchurch (UCL Earth Sciences), co-author of the Biological Reviews study, added: "Several previous methodological studies have shown that it is important to include as many species in an evolutionary tree as possible: this generally improves the accuracy of the tree. By producing such a large data set, we hope that our evolutionary tree for Paleocene mammals is more robust and reliable than any of the previous ones. Moreover, such large trees are very useful for future studies of large-scale evolutionary patterns, such as how early placental mammals dispersed across the continents via land bridges that no longer exist today."

The team are now investigating rates of evolution in these mammals, as well as looking at body size more specifically. Further work will involve building data from DNA into these analyses, to extend these studies to modern mammals.

Source: University College London [December 21, 2015]

The horticulturist who came up with the concept of ‘evolution by natural selection’ 27 years before Charles Darwin did should be more widely acknowledged for his contribution, states a new paper by a King’s College London geneticist.

The paper, published in the Biological Journal of the Linnean Society, argues that Patrick Matthew deserves to be considered alongside Charles Darwin and Alfred Russel Wallace as one of the three originators of the idea of large-scale evolution by natural selection.

Furthermore, Matthew’s version of evolution by natural section captures a valuable aspect of the theory that isn't so clear in Darwin's version – namely, that natural selection is a deductive certainty more akin to a ‘law’ than a hypothesis or theory to be tested.

Patrick Matthew (1790-1874) was a Scottish landowner with a keen interest in politics and agronomy.  He established extensive orchards of apples and pears on his estate at Gourdie Hill, Perthshire, and became adept in horticulture, silviculture and agriculture.

Whilst Darwin and Wallace’s 1858 paper to the Linnean Society, On the Origin of Species, secured their place in the history books, Matthews had set out similar ideas 27 years earlier in his book On Naval Timber and Arboriculture. The book, published in 1831, addressed best practices for the cultivation of trees for shipbuilding, but also expanded on his concept of natural selection.

“There is a law universal in nature, tending to render every reproductive being the best possibly suited to its condition that its kind, or that organized matter, is susceptible of, which appears intended to model the physical and mental or instinctive powers, to their highest perfection, and to continue them so. This law sustains the lion in his strength, the hare in her swiftness, and the fox in his wiles.”  (Matthew, 1831: 364)

In 1860, Matthew wrote to point out the parallels with his prior work, several months after the publication of On the origin of species.  Darwin publically wrote in 1860 “I freely acknowledge that Mr. Matthew has anticipated by many years the explanation which I have offered of the origin of species”, while Wallace wrote publically in 1879 of “how fully and clearly Mr. Matthew apprehended the theory of natural selection, as well as the existence of more obscure laws of evolution, many years in advance of Mr. Darwin and myself”, and further declared Matthew to be “one of the most original thinkers of the first half of the 19th century”.  However, both asserted their formulations were independent of Matthew’s.

Even if Matthew did not influence Darwin and Wallace, his writings provide a valuable third point of reference on the notion of macroevolution by natural selection, argues the paper’s author, Dr Michael Weale. Dr Weale has created a public website to act as an online repository of the writings by Patrick Matthew, including some of his lesser-known work.

Dr Michael Weale, from the Department of Medical and Molecular Genetics at King’s College London, said: ‘Whilst Darwin and Wallace both deserve recognition for their work, Matthew, the outsider who deduced his idea as part of a grand scheme of a purposeful universe, is the overlooked third man in the story. Matthew’s story is an object lesson in the perils of low-impact publishing. Despite its brevity, and to some extent because of it, Matthew’s work merits our renewed attention.’

Source: King's College London [April 20, 2015]

Scientists from Wageningen UR and other institutes are proposing a new research model - the turnover model - as a way of answering the question why there are always so many plant species in tropical rainforests.

In their publication in New Phytologist magazine, the Dutch, British and Swiss scientists show that major evolutionary changes, such as the origin of large groups of species, occur with a reasonably constant frequency while the origin of new species is an explosive process.

Various models

Darwin’s contemporary Alfred Russel Wallace already argued that the Tropics are, in essence, a museum of biodiversity. As tropical climates are stable, Wallace suggested that species would gradually increase in number over longer time periods, the so-called museum model. More recently, however, it was suggested that the Pleistocene ice ages, and the impact thereof on the climate in the Tropics, resulted in recent explosions of speciation, the so-called cradle model.

Both models are supported by previous research into patterns of diversification in tropical plants. This research is performed by means of reconstructed ‘phylogenetic trees’; genealogical trees that show the interrelated  descent of plant species. Where analyses of plant families focused on studying as many evolutionary lines as possible from the family, diversity was shown to increase gradually. For instance, the development of diversity in important tropical plant groups such as palm trees, the leguminous family and the soursop family, appear to follow the museum model. However, within these large plant families there are also plant genera that seem to follow the cradle model: so-called radiations in which many different species developed recently and over a short period of time.

Equatiing seems impossible

Equating these two models seems an impossible task. How can a large plant family that presents an explosive increase in the number of species diversify as an entire family following the museum model? The answer lies in analysing more species per family, and better modelling speciation over long periods in evolution via the computer.

Mahogany trees

Scientists from Wageningen UR, Kew (London) and Zürich compiled the largest amount of data so far for the Meliaceae , or mahogany family. This family mainly grows in the Tropics, and is known for valuable wood such as mahogany and Spanish cedar. Parts of the nuclear and chloroplast genome of approximately 35% of the species were sequenced; a technology in which all the building blocks of the DNA are mapped.

The analysis of evolutionary diversification showed that the diversity of larger groups, such as plant genera and families, does develop in accordance with the museum model, i.e., with a certain constant frequency in the origin of new branches. The scientists showed that, in addition to this ‘museum fundament’, the origin of individual species is an explosive process which occurs in accordance with the cradle model.

‘Young’ species

The research shows that the mahogany family developed approximately 68 million years ago. The circa 200 mahogany species that grow in the South American rainforests are largely the result of two explosions in speciation (radiations) that occurred independently in two evolutionary lines in the late Miocene epoch, which was less than 10 million years ago.

An interesting aspect of this explosive origin of large numbers of species within the mahogany family is that it involves two different groups within the family which independently evolved the same ecological adaptations, such as plant height and an adaptation of seeds to the same animal species that distribute them. In addition, the two groups show a similar speed of speciation. These abrupt increases in speciation speed occurred after the mahogany family had left its original habitat (tropical dry forests and seasonal forests) and colonised the rainforests, where they were faced with different climate conditions.

New model for evolution

The results of the study show that most mahogany species in the Tropics are relatively recent. It can be assumed that this also applies to other families. The authors propose a new model, the turnover model, in which the number of evolutionary lines increases with a more or less constant speed, while speciation occurs separately and in a more explosive way.

Source: Wageningen University [June 19, 2015]

Scientists from the University of Liverpool have developed computer models of the bodies of sauropod dinosaurs to examine the evolution of their body shape.

Sauropod dinosaurs include the largest land animals to have ever lived. Some of the more well-known sauropods include Diplodocus, Apatosaurus and Brontosaurus. They are renowned for their extremely long necks, long tails as well as four thick, pillar-like legs and small heads in relation to their body.

To date, however, there have been only limited attempts to examine how this unique body-plan evolved and how it might be related to their gigantic body size. Dr Karl Bates from the University's Department of Musculoskeletal Biology and his colleagues used three-dimensional computer models reconstructing the bodies of sauropod dinosaurs to analyse how their size, shape and weight-distribution evolved over time.

Evolutionary history

Dr Bates found evidence that changes in body shape coincided with major events in sauropod evolutionary history such as the rise of the titanosaurs. The early dinosaurs that sauropods evolved from were small and walked on two legs, with long tails, small chests and small forelimbs. The team estimate that this body shape concentrated their weight close to the hip joint, which would have helped them balance while walking bipedally on their hind legs.

As sauropods evolved they gradually altered both their size and shape from this ancestral template, becoming not only significantly larger and heavier, but also gaining a proportionally larger chest, forelimbs and in particular a dramatically larger neck.

>A Giraffatitan model of a Sauropod showing how the centre of mass is moved by> reconstructing the soft tissues differently using the convex hulling approach >[Credit: Dr Peter L Falkingham/Liverpool John Moores University]
The team's findings show that these changes altered sauropods' weight distribution as they grew in size, gradually shifting from being tail-heavy, two-legged animals to being front-heavy, four-legged animals, such as the large, fully quadrupedal Jurassic sauropods Diplodocus and Apatosaurus.

The team found that these linked trends in size, body shape and weight distribution did not end with the evolution of fully quadrupedal sauropods. In the Cretaceous period - the last of the three ages of the dinosaurs - many earlier sauropod groups dwindled. In their place, a new and extremely large type of sauropod known as titanosaurs evolved, including the truly massive Argentinosaurus and Dreadnoughtus, among the largest known animals ever to have lived.

Front heavy

The team's computer models suggest that in addition to their size, the titanosaurs evolved the most extreme 'front heavy' body shape of all sauropods, as a result of their extremely long necks.

Dr Bates said: "As a result of devising these models we were able to ascertain that the relative size of sauropods' necks increased gradually over time, leading to animals that were increasingly more front-heavy relative to their ancestors."

Dr Philip Mannion from Imperial College London, a collaborator in the research, added: "These innovations in body shape might have been key to the success of titanosaurs, which were the only sauropod dinosaurs to survive until the end-Cretaceous mass extinction, 66 million years ago."

Dr Vivian Allen from the Royal Veterinary College London, who also collaborated in the research, added: "What's important to remember about studies like this is that there is a very high degree of uncertainty about exactly how these animals were put together. While we have good skeletons for many of them, it's difficult to be sure how much meat there was around each of the bones. We have built this uncertainly into our models, ranging each body part from emaciated to borderline obesity, and even using these extremes we still find these solid, trending changes in body proportions over sauropod evolution."

The paper has been published by the Royal Society Open Science journal.

Source: University of Liverpool [March 29, 2016]

Mammals immortalise their genes through eggs and sperm to ensure future generations inherit good quality mitochondria to power the body's cells, according to new UCL research.

Before now, it was not known why mammals rely on dedicated sex cells that are formed early in development (a germline) to make offspring whereas plants and other simple animals, such as corals and sponges, use sex cells produced later in life from normal body tissues.

In a new study, published today in >PLOS Biology and funded by Natural Environment Research Council, Engineering & Physical Sciences Research Council and the Leverhulme Trust, UCL scientists developed an evolutionary model to investigate how these differences evolved over time and discovered that the germline in mammals developed in response to selection on mitochondria (the powerhouses of cells).

First author and UCL PhD student, Arunas Radzvilavicius, said: "There have been many theories about why mammals have a specialised germline when plants and other ancient animals don't. Some suggest it was due to complexity of tissues or a selfish conflict between cells. The distinction between sex cells and normal body tissues seems to be necessary for the evolution of very complex specialised tissues like brain.

"Surprisingly, we found that these aren't the reason. Rather, it's about the number of genetic mutations in mitochondrial DNA over time, which differs between organisms, and the variation between cells caused by the mitochondria being randomly partitioned into daughter cells at each division."

In plants, mitochondrial mutations creep in slowly, so a germline isn't needed as mutations are corrected by natural selection. Mitochondrial variation is maximised by forming the next generation from the same cells used to make normal tissue cells. When the cells divide to form new daughter cells, some receive more mutant mitochondria than others and these cells are then removed through natural selection, preserving the reproductive cells containing higher quality mitochondria.

In mammals, genetic errors in mitochondria accumulate more quickly due to our higher metabolic rate so using cells that have undergone lots of division cycles would be a liability. Mitochondria are therefore only passed along to the next generation through a dedicated female germline in the form of large eggs. This protects against errors being introduced as eggs undergo many fewer replication cycles than cells in other tissues such as the gut, skin and blood.

The germline ensures that the best quality mitochondria are transferred but restricts the genetic variation in the next generation of cells in the developing embryo. This is corrected for by mammals generating far too many egg cells which are removed during development. For example, humans are born with over 6 million egg-precursor cells, 90% of which are culled by the start of puberty in a mysterious process called atresia.

Senior author, Dr Nick Lane (UCL CoMPLEX and Genetics, Evolution & Environment) added: "We think the rise in mitochondrial mutation rate likely occurred in the Cambrian explosion 550 million years ago when oxygen levels rose. This was the first appearance of motile animals in the fossil record, things like trilobites that had eyes and armour plating - predators and prey. By moving around they used their mitochondria more and that increased the mutation rate. So to avoid these mutations accumulating they needed to have fewer rounds of cell division, and that meant sequestering a specialized germline."

Co-author, Professor Andrew Pomiankowski (UCL Genetics, Evolution & Environment), concluded: "Without a germline, animals with complex development and brains could not exist. Scientists have long tried to explain the evolution of the germline in terms of complexity. Who would have thought it arose from selection on mitochondrial genes? We hope our discovery will transform the way researchers understand animal development, reproduction and aging."

Source: University College London [December 20, 2016]

On the outskirts of Beijing, a small limestone mountain named Dragon Bone Hill rises above the surrounding sprawl. Along the northern side, a path leads up to some fenced-off caves that draw 150,000 visitors each year, from schoolchildren to grey-haired pensioners. It was here, in 1929, that researchers discovered a nearly complete ancient skull that they determined was roughly half a million years old. Dubbed Peking Man, it was among the earliest human remains ever uncovered, and it helped to convince many researchers that humanity first evolved in Asia.

Since then, the central importance of Peking Man has faded. Although modern dating methods put the fossil even earlier—at up to 780,000 years old—the specimen has been eclipsed by discoveries in Africa that have yielded much older remains of ancient human relatives. Such finds have cemented Africa's status as the cradle of humanity—the place from which modern humans and their predecessors spread around the globe—and relegated Asia to a kind of evolutionary cul-de-sac.

But the tale of Peking Man has haunted generations of Chinese researchers, who have struggled to understand its relationship to modern humans. "It's a story without an ending," says Wu Xinzhi, a palaeontologist at the Chinese Academy of Sciences' Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) in Beijing. They wonder whether the descendants of Peking Man and fellow members of the species Homo erectus died out or evolved into a more modern species, and whether they contributed to the gene pool of China today.

Keen to get to the bottom of its people's ancestry, China has in the past decade stepped up its efforts to uncover evidence of early humans across the country. It is reanalysing old fossil finds and pouring tens of millions of dollars a year into excavations. And the government is setting up a US$1.1-million laboratory at the IVPP to extract and sequence ancient DNA.

The investment comes at a time when palaeoanthropologists across the globe are starting to pay more attention to Asian fossils and how they relate to other early hominins—creatures that are more closely related to humans than to chimps. Finds in China and other parts of Asia have made it clear that a dazzling variety of Homo species once roamed the continent. And they are challenging conventional ideas about the evolutionary history of humanity.

"Many Western scientists tend to see Asian fossils and artefacts through the prism of what was happening in Africa and Europe," says Wu. Those other continents have historically drawn more attention in studies of human evolution because of the antiquity of fossil finds there, and because they are closer to major palaeoanthropology research institutions, he says. "But it's increasingly clear that many Asian materials cannot fit into the traditional narrative of human evolution."

Chris Stringer, a palaeoanthropologist at the Natural History Museum in London, agrees. "Asia has been a forgotten continent," he says. "Its role in human evolution may have been largely under-appreciated."

Evolving story

In its typical form, the story of Homo sapiens starts in Africa. The exact details vary from one telling to another, but the key characters and events generally remain the same. And the title is always 'Out of Africa'.

In this standard view of human evolution, H. erectus first evolved there more than 2 million years ago. Then, some time before 600,000 years ago, it gave rise to a new species: Homo heidelbergensis, the oldest remains of which have been found in Ethiopia. About 400,000 years ago, some members of H. heidelbergensis left Africa and split into two branches: one ventured into the Middle East and Europe, where it evolved into Neanderthals; the other went east, where members became Denisovans—a group first discovered in Siberia in 2010. The remaining population of H. heidelbergensis in Africa eventually evolved into our own species, H. sapiens, about 200,000 years ago. Then these early humans expanded their range to Eurasia 60,000 years ago, where they replaced local hominins with a minuscule amount of interbreeding.

A hallmark of H. heidelbergensis—the potential common ancestor of Neanderthals, Denisovans and modern humans—is that individuals have a mixture of primitive and modern features. Like more archaic lineages, H. heidelbergensis has a massive brow ridge and no chin. But it also resembles H. sapiens, with its smaller teeth and bigger braincase. Most researchers have viewed H. heidelbergensis—or something similar—as a transitional form between H. erectus and H. sapiens.

Unfortunately, fossil evidence from this period, the dawn of the human race, is scarce and often ambiguous. It is the least understood episode in human evolution, says Russell Ciochon, a palaeoanthropologist at the University of Iowa in Iowa City. "But it's central to our understanding of humanity's ultimate origin."

The tale is further muddled by Chinese fossils analysed over the past four decades, which cast doubt over the linear progression from African H. erectus to modern humans. They show that, between roughly 900,000 and 125,000 years ago, east Asia was teeming with hominins endowed with features that would place them somewhere between H. erectus and H. sapiens, says Wu.

"Those fossils are a big mystery," says Ciochon. "They clearly represent more advanced species than H. erectus, but nobody knows what they are because they don't seem to fit into any categories we know."

The fossils' transitional characteristics have prompted researchers such as Stringer to lump them with H. heidelbergensis. Because the oldest of these forms, two skulls uncovered in Yunxian in Hubei province, date back 900,000 years >^{1, 2}>, Stringer even suggests that H. heidelbergensis might have originated in Asia and then spread to other continents.

But many researchers, including most Chinese palaeontologists, contend that the materials from China are different from European and African H. heidelbergensis fossils, despite some apparent similarities. One nearly complete skull unearthed at Dali in Shaanxi province and dated to 250,000 years ago, has a bigger braincase, a shorter face and a lower cheekbone than most H. heidelbergensis specimens>3, suggesting that the species was more advanced.

Such transitional forms persisted for hundreds of thousands of years in China, until species appeared with such modern traits that some researchers have classified them as H. sapiens. One of the most recent of these is represented by two teeth and a lower jawbone, dating to about 100,000 years ago, unearthed in 2007 by IVPP palaeoanthropologist Liu Wu and his colleagues>4. Discovered in Zhirendong, a cave in Guangxi province, the jaw has a classic modern-human appearance, but retains some archaic features of Peking Man, such as a more robust build and a less-protruding chin.

Most Chinese palaeontologists—and a few ardent supporters from the West—think that the transitional fossils are evidence that Peking Man was an ancestor of modern Asian people. In this model, known as multiregionalism or continuity with hybridization, hominins descended from H. erectus in Asia interbred with incoming groups from Africa and other parts of Eurasia, and their progeny gave rise to the ancestors of modern east Asians, says Wu.

Support for this idea also comes from artefacts in China. In Europe and Africa, stone tools changed markedly over time, but hominins in China used the same type of simple stone instruments from about 1.7 million years ago to 10,000 years ago. According to Gao Xing, an archaeologist at the IVPP, this suggests that local hominins evolved continuously, with little influence from outside populations.

Politics at play?

Some Western researchers suggest that there is a hint of nationalism in Chinese palaeontologists' support for continuity. "The Chinese—they do not accept the idea that H. sapiens evolved in Africa," says one researcher. "They want everything to come from China."

Chinese researchers reject such allegations. "This has nothing to do with nationalism," says Wu. It's all about the evidence—the transitional fossils and archaeological artefacts, he says. "Everything points to continuous evolution in China from H. erectus to modern human."

But the continuity-with-hybridization model is countered by overwhelming genetic data that point to Africa as the wellspring of modern humans. Studies of Chinese populations show that 97.4% of their genetic make-up is from ancestral modern humans from Africa, with the rest coming from extinct forms such as Neanderthals and Denisovans>5. "If there had been significant contributions from Chinese H. erectus, they would show up in the genetic data," says Li Hui, a population geneticist at Fudan University in Shanghai. Wu counters that the genetic contribution from archaic hominins in China could have been missed because no DNA has yet been recovered from them.

Many researchers say that there are ways to explain the existing Asian fossils without resorting to continuity with hybridization. The Zhirendong hominins, for instance, could represent an exodus of early modern humans from Africa between 120,000 and 80,000 years ago. Instead of remaining in the Levant in the Middle East, as was thought previously, these people could have expanded into east Asia, says Michael Petraglia, an archaeologist at the University of Oxford, UK.

Other evidence backs up this hypothesis: excavations at a cave in Daoxian in China's Hunan province have yielded 47 fossil teeth so modern-looking that they could have come from the mouths of people today. But the fossils are at least 80,000 years old, and perhaps 120,000 years old, Liu and his colleagues reported last year>6. "Those early migrants may have interbred with archaic populations along the way or in Asia, which could explain Zhirendong people's primitive traits," says Petraglia.

Another possibility is that some of the Chinese fossils, including the Dali skull, represent the mysterious Denisovans, a species identified from Siberian fossils that are more than 40,000 years old. Palaeontologists don't know what the Denisovans looked like, but studies of DNA recovered from their teeth and bones indicate that this ancient population contributed to the genomes of modern humans, especially Australian Aborigines, Papua New Guineans and Polynesians—suggesting that Denisovans might have roamed Asia.

Maria Martinon-Torres, a palaeoanthropologist at University College London, is among those who proposed that some of the Chinese hominins were Denisovans. She worked with IVPP researchers on an analysis>7, published last year, of a fossil assemblage uncovered at Xujiayao in Hebei province—including partial jaws and nine teeth dated to 125,000–100,000 years ago. The molar teeth are massive, with very robust roots and complex grooves, reminiscent of those from Denisovans, she says.

A third idea is even more radical. It emerged when Martinon-Torres and her colleagues compared more than 5,000 fossil teeth from around the world: the team found that Eurasian specimens are more similar to each other than to African ones>8. That work and more recent interpretations of fossil skulls suggest that Eurasian hominins evolved separately from African ones for a long stretch of time. The researchers propose that the first hominins that left Africa 1.8 million years ago were the eventual source of modern humans. Their descendants mostly settled in the Middle East, where the climate was favourable, and then produced waves of transitional hominins that spread elsewhere. One Eurasian group went to Indonesia, another gave rise to Neanderthals and Denisovans, and a third ventured back into Africa and evolved into H. sapiens, which later spread throughout the world. In this model, modern humans evolved in Africa, but their immediate ancestor originated in the Middle East.

Not everybody is convinced. "Fossil interpretations are notoriously problematic," says Svante Paabo, a palaeogeneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. But DNA from Eurasian fossils dating to the start of the human race could help to reveal which story—or combination—is correct. China is now making a push in that direction. Qiaomei Fu, a palaeogeneticist who did her PhD with Paabo, returned home last year to establish a lab to extract and sequence ancient DNA at the IVPP. One of her immediate goals is to see whether some of the Chinese fossils belong to the mysterious Denisovan group. The prominent molar teeth from Xujiayao will be an early target. "I think we have a prime suspect here," she says.

Fuzzy picture

Despite the different interpretations of the Chinese fossil record, everybody agrees that the evolutionary tale in Asia is much more interesting than people appreciated before. But the details remain fuzzy, because so few researchers have excavated in Asia.

When they have, the results have been startling. In 2003, a dig on Flores island in Indonesia turned up a diminutive hominin>9, which researchers named Homo floresiensis and dubbed the hobbit. With its odd assortment of features, the creature still provokes debate about whether it is a dwarfed form of H. erectus or some more primitive lineage that made it all the way from Africa to southeast Asia and lived until as recently as 60,000 years ago. Last month, more surprises emerged from Flores, where researchers found the remains of a hobbit-like hominin in rocks about 700,000 years old>10.

Recovering more fossils from all parts of Asia will clearly help to fill in the gaps. Many palaeoanthropologists also call for better access to existing materials. Most Chinese fossils—including some of the finest specimens, such as the Yunxian and Dali skulls—are accessible only to a handful of Chinese palaeontologists and their collaborators. "To make them available for general studies, with replicas or CT scans, would be fantastic," says Stringer. Moreover, fossil sites should be dated much more rigorously, preferably by multiple methods, researchers say.

But all agree that Asia—the largest continent on Earth—has a lot more to offer in terms of unravelling the human story. "The centre of gravity," says Petraglia, "is shifting eastward."

Author: Jane Qiu | Source: Nature 535, 22–25 (14 July 2016) doi:10.1038/535218a [July 15, 2016]

It took 100 million years for oxygen levels in the oceans and atmosphere to increase to the level that allowed the explosion of animal life on Earth about 600 million years ago, according to a UCL-led study funded by the Natural Environment Research Council.

Before now it was not known how quickly Earth's oceans and atmosphere became oxygenated and if animal life expanded before or after oxygen levels rose. The new study, published today in Nature Communications, shows the increase began significantly earlier than previously thought and occurred in fits and starts spread over a vast period. It is therefore likely that early animal evolution was kick-started by increased amounts of oxygen, rather than a change in animal behaviour leading to oxygenation.

Lead researcher, Dr Philip Pogge von Strandmann (UCL Earth Sciences), said: "We want to find out how the evolution of life links to the evolution of our climate. The question on how strongly life has actively modified Earth's climate, and why the Earth has been habitable for so long is extremely important for understanding both the climate system, and why life is on Earth in the first place."

Researchers from UCL, Birkbeck, Bristol University, University of Washington, University of Leeds, Utah State University and University of Southern Denmark tracked what was happening with oxygen levels globally 770 - 520 million years ago (Ma) using new tracers in rocks across the US, Canada and China.

Samples of rocks that were laid down under the sea at different times were taken from different locations to piece together the global picture of the oxygen levels of Earth's oceans and atmosphere. By measuring selenium isotopes in the rocks, the team revealed that it took 100 million years for the amount of oxygen in the atmosphere to climb from less than 1% to over 10% of today's current level. This was arguably the most significant oxygenation event in Earth history because it ushered in an age of animal life that continues to this day.

Dr Pogge von Strandmann, said: "We took a new approach by using selenium isotope tracers to analyse marine shales which gave us more information about the gradual changes in oxygen levels than is possible using the more conventional techniques used previously. We were surprised to see how long it took Earth to produce oxygen and our findings dispel theories that it was a quick process caused by a change in animal behaviour."

During the period studied, three big 'snowball Earth' glaciations - Sturtian (~716Ma), Marinoan (~635Ma) and Gaskiers (~580Ma) - occurred whereby the Earth's land was covered in ice and most of the oceans were frozen from the poles to the tropics. During these periods, temperatures plummeted and rose again, causing glacial melting and an influx of nutrients into the ocean, which researchers think caused oxygen levels to rise deep in the oceans.

Increased nutrients means more ocean plankton, which will bury organic carbon in seafloor sediments when they die. Burying carbon results in oxygen increasing, dramatically changing conditions on Earth. Until now, oxygenation was thought to have occurred after the relatively small Gaskiers glaciation melted. The findings from this study pushes it much earlier, to the Marinoan glaciation, after which animals began to flourish in the improved conditions, leading to the first big expansion of animal life.

Co-author Prof. David Catling (University of Washington Earth and Space Sciences), added: "Oxygen was like a slow fuse to the explosion of animal life. Around 635 Ma, enough oxygen probably existed to support tiny sponges. Then, after 580 Ma, strange creatures shaped like pizzas lived on a lightly oxygenated seafloor. Fifty million years later, vertebrate ancestors were gliding through oxygen-rich seawater. Tracking how oxygen increased is the first step towards understanding why it took so long. Ultimately, a grasp of geologic controls on oxygen levels can help us understand whether animal-like life might exist or not on Earth-like planets elsewhere."

Source: University College London [December 17, 2015]

An intriguing study involving walking stick insects led by the University of Sheffield in England and the University of Colorado Boulder shows how natural selection, the engine of evolution, can also impede the formation of new species.

The team studied a plant-eating stick insect species from California called Timema cristinae known for its cryptic camouflage that allows it to hide from hungry birds, said CU-Boulder Assistant Professor Samuel Flaxman. T. cristinae comes in several different types -- one is green and blends in with the broad green leaves of a particular shrub species, while a second green variant sports a white, vertical stripe that helps disguise it on a different species of shrub with narrow, needle-like leaves.

While Darwinian natural selection has begun pushing the two green forms of walking sticks down separate paths that could lead to the formation of two new species, the team found that a third melanistic, or brown variation of T. cristinae appears to be thwarting the process, said Flaxman. The brown version is known to successfully camouflage itself among the stems of both shrub species inhabited by its green brethren, he said.

Using field investigations, laboratory genetics, modern genome sequencing and computer simulations, the team concluded the brown version of T. cristinae is shuttling enough genes between the green stick insects living on different shrubs to prevent strong divergent adaptation and speciation. The brown variant of the walking stick species also is favored by natural selection because it has a slight advantage in mate selection and a stronger resistance to fungal infections than its green counterparts.

"This is one of the best demonstrations we know of regarding the counteractive effects of natural selection on speciation," said Flaxman of CU-Boulder's Department of Ecology and Evolutionary Biology, second author on the new study. "We show how the brown population essentially carries genes back and forth between the green populations, acting as a genetic bridge that causes a slowdown in divergence."

A paper on the subject appeared in a recent issue of the journal Current Biology. Other study co-authors were from the University of Sheffield, Royal Holloway University of London, Utah State University, the University of Nevada, Reno and the University of Lausanne in Switzerland.

"This movement of genes between environments slows down the genetic divergence of these stick insect populations, impeding the formation of new species," said Aaron Comeault, a former CU-Boulder graduate student and lead study author who conducted the research while at the University of Sheffield. Comeault is now a postdoctoral researcher at the University of North Carolina at Chapel Hill.

The new results underscore how combining natural history and cutting-edge genetics can help researchers gain a better understanding of how evolution operates in nature. It also shows how natural selection can sometimes promote but other times hinder the formation of new species, according to the research team.

Walking sticks are one of nature's oddest insect groups and range in size from the half-inch long T. cristinae to species in Borneo and Vietnam that are more than a foot long. Most walking sticks rely on plant mimicry to protect them from predators.

Source: University of Colorado at Boulder [August 06, 2015]

It has long puzzled scientists why, after 3 billion years of nothing more complex than algae, complex animals suddenly started to appear on Earth. Now, a team of researchers has put forward some of the strongest evidence yet to support the hypothesis that high levels of oxygen in the oceans were crucial for the emergence of skeletal animals 550 million years ago.

The new study is the first to distinguish between bodies of water with low and high levels of oxygen. It shows that poorly oxygenated waters did not support the complex life that evolved immediately prior to the Cambrian period, suggesting the presence of oxygen was a key factor in the appearance of these animals.

Lead author Dr Rosalie Tostevin completed the study analyses as part of her PhD with UCL Earth Sciences, and is now in the Department of Earth Sciences at Oxford University. She said: 'The question of why it took so long for complex animal life to appear on Earth has puzzled scientists for a long time. One argument has been that evolution simply doesn't happen very quickly, but another popular hypothesis suggests that a rise in the level of oxygen in the oceans gave simple life-forms the fuel they needed to evolve skeletons, mobility and other typical features of modern animals.

'Although there is geochemical evidence for a rise in oxygen in the oceans around the time of the appearance of more complex animals, it has been really difficult to prove a causal link. By teasing apart waters with high and low levels of oxygen, and demonstrating that early skeletal animals were restricted to well-oxygenated waters, we have provided strong evidence that the availability of oxygen was a key requirement for the development of these animals. However, these well-oxygenated environments may have been in short supply, limiting habitat space in the ocean for the earliest animals.'

The team, which included other geochemists, palaeoecologists and geologists from UCL and the universities of Edinburgh, Leeds and Cambridge, as well as the Geological Survey of Namibia, analysed the chemical elemental composition of rock samples from the ancient seafloor in the Nama Group - a group of extremely well-preserved rocks in Namibia that are abundant with fossils of early Cloudina, Namacalathus and Namapoikia animals.

The researchers found that levels of elements such as cerium and iron detected in the rocks showed that low-oxygen conditions occurred between well-oxygenated surface waters and fully 'anoxic' deep waters. Although abundant in well-oxygenated environments, early skeletal animals did not occupy oxygen-impoverished regions of the shelf, demonstrating that oxygen availability (probably >10 micromolar) was a key requirement for the development of early animal-based ecosystems.

Professor Graham Shields-Zhou (UCL Earth Sciences), one of the co-authors and Dr Tostevin's PhD supervisor, said: 'We honed in on the last 10 million years of the Proterozoic Eon as the interval of Earth's history when today's major animal groups first grew shells and churned up the sediment, and found that oxygen levels were important to the relationship between environmental conditions and the early development of animals.'

The research, based on fieldwork carried out in the Nama Group in Namibia, is published in the >journal Nature Communications.

Source: University College London [September 23, 2016]

Photosynthesis is the process by which plants, algae and cyanobacteria use the energy from the Sun to make sugar from water and carbon dioxide, releasing oxygen as a waste product. But a few groups of bacteria carry out a simpler form of photosynthesis that does not produce oxygen, which evolved first.

A new study by an Imperial researcher suggests that this more primitive form of photosynthesis evolved in much more ancient bacteria than scientists had imagined, more than 3.5 billion years ago.

Photosynthesis sustains life on Earth today by releasing oxygen into the atmosphere and providing energy for food chains. The rise of oxygen-producing photosynthesis allowed the evolution of complex life forms like animals and land plants around 2.4 billion years ago.

However, the first type of photosynthesis that evolved did not produce oxygen. It was known to have first evolved around 3.5-3.8 billion years ago, but until now, scientists thought that one of the groups of bacteria alive today that still uses this more primate photosynthesis was the first to evolve the ability.

But the new research reveals that a more ancient bacteria, that probably no longer exists today, was actually the first to evolve the simpler form of photosynthesis, and that this bacteria was an ancestor to most bacteria alive today.

"The picture that is starting to emerge is that during the first half of Earth's history the majority of life forms were probably capable of photosynthesis," said study author Dr Tanai Cardona, from the Department of Life Sciences at Imperial College London.

The more primitive form of photosynthesis is known as anoxygenic photosynthesis, which uses molecules such as hydrogen, hydrogen sulfide, or iron as fuel -- instead of water.

Traditionally, scientists had assumed that one of the groups of bacteria that still use anoxygenic photosynthesis today evolved the ability and then passed it on to other bacteria using horizontal gene transfer -- the process of donating an entire set of genes, in this case those required for photosynthesis, to unrelated organisms.

However, Dr Cardona created an evolutionary tree for the bacteria by analyzing the history of a protein essential for anoxygenic photosynthesis. Through this, he was able to uncover a much more ancient origin for photosynthesis.

Instead of one group of bacteria evolving the ability and transferring it to others, Dr Cardona's analysis reveals that anoxygenic photosynthesis evolved before most of the groups of bacteria alive today branched off and diversified. The results are published in the journal PLOS ONE.

"Pretty much every group of photosynthetic bacteria we know of has been suggested, at some point or another, to be the first innovators of photosynthesis," said Dr Cardona. "But this means that all these groups of bacteria would have to have branched off from each other before anoxygenic photosynthesis evolved, around 3.5 billion years ago.

"My analysis has instead shown that anoxygenic photosynthesis predates the diversification of bacteria into modern groups, so that they all should have been able to do it. In fact, the evolution of oxygneic photosynthesis probably led to the extinction of many groups of bacteria capable of anoxygenic photosynthesis, triggering the diversification of modern groups."

To find the origin of anoxygenic photosynthesis, Dr Cardona traced the evolution of BchF, a protein that is key in the biosynthesis of bacteriochlorophyll a, the main pigment employed in anoxygenic photosynthesis. The special characteristic of this protein is that it is exclusively found in anoxygenic photosynthetic bacteria and without it bacteriochlorophyll a cannot be made.

By comparing sequences of proteins and reconstructing an evolutionary tree for BchF, he discovered that it originated before most described groups of bacteria alive today.

Author: Hayley Dunning | Source: Imperial College London [March 15, 2016]

Placental mammals consist of three main groups that diverged rapidly, evolving in wildly different directions: Afrotheria (for example, elephants and tenrecs), Xenarthra (such as armadillos and sloths) and Boreoeutheria (all other placental mammals). The relationships between them have been a subject of fierce controversy with multiple studies coming to incompatible conclusions over the last decade leading some researchers to suggest that these relationships might be impossible to resolve.

There are thus many outstanding questions such as which is the oldest sibling of the three? Did the mammals go their separate ways due to South America and Africa breaking apart? And if not, when did placentals split up?

"This has been one of the areas of greatest debate in evolutionary biology, with many researchers considering it impossible to resolve," said lead author Dr Tarver of Bristol's School of Earth Sciences. "Now we've proven these problems can be solved -- you just need to analyse genome-scale datasets using models that accurately reflect genomic evolution."

The researchers assembled the largest mammalian phylogenomic dataset ever collected before testing it with a variety of models of molecular evolution, choosing the most robust model and then analysing the data using several supercomputer clusters at the University of Bristol and the University of Texas Advanced Computing Centre. "We tested it to destruction," said Dr Tarver. "We threw the kitchen sink at it."

"A complication in reconstructing evolutionary histories from genomic data is that different parts of genomes can and often do give conflicting accounts of the history," said Dr Siavash Mirarab at the University of California San Diego, USA. "Individual genes within the same species can have different histories. This is one reason why the controversy has stood so long -- many thought the relationships couldn't be resolved."

To address the complexities of analysing large numbers of genes shared among many species, the researchers paired two fundamentally different approaches -- concatenated and coalescent-based analyses -- to confirm the findings. When the dust settled, the team had a specific family tree showing that Atlantogenata (containing the sibling groups of African Afrotheria and the South American Xenarthra) is the sister group to all other placentals.

Because many conflicting family trees have already been published, the team then gathered three of the most influential rivals and tested them against each other with the same model. All of the previous studies suddenly fell into line, their data agreeing with Tarver and colleagues.

With the origins of the family tree resolved, what does this mean for placental mammals? The researchers folded in another layer -- a molecular clock analysis. "The molecular clock analysis uses a combination of fossils and genomic data to estimate when these lineages diverged from each other," said author Dr Mario Dos-Reis of Queen Mary London, UK. "The results show that the afrotherians and xenarthrens diverged from one another around 90 million years ago."

Previously, scientists thought that when Africa and South America separated from each other over 100 million years ago, they broke up the family of placental mammals, who went their separate evolutionary ways divided by geography. But the researchers found that placental mammals didn't split up until after Africa and South America had already separated.

"We propose that South America's living endemic Xenarthra (for exmaple, sloths, anteaters, and armadillos) colonized the island-continent via overwater dispersal," said study author Dr Rob Asher of the University of Cambridge, UK.

Dr Asher suggests that this isn't as difficult as you might think. Mammals are among the great adventurers of the animal kingdom, and at the time the proto-Atlantic was only a few hundred miles wide. We already know that New World monkeys crossed the Atlantic later, when it was much bigger, probably on rafts formed from storm debris. And, of course, mammals repeatedly colonised remote islands like Madagascar.

"You don't always need to overturn the status quo to make a big impact," said Dr Tarver. "All of the competing hypotheses had some evidence to support them -- that's precisely why it was the source of such controversy. Proving the roots of the placental family tree with hard empirical evidence is a massive accomplishment."

The findings are published in Genome Biology and Evolution journal.

Source: University of Bristol [February 15, 2016]

Consider the engineering marvel that is your foot. Be it hairy or homely, without its solid support you'd be hard-pressed to walk or jump normally.

Now, researchers at the Stanford University School of Medicine and the HudsonAlpha Institute for Biotechnology in Huntsville, Alabama, have identified a change in gene expression between humans and primates that may have helped give us this edge when it comes to walking upright. And they did it by studying a tiny fish called the threespine stickleback that has evolved radically different skeletal structures to match environments around the world.

"It's somewhat unusual to have a research project that spans from fish all the way to humans, but it's clear that tweaking the expression levels of molecules called bone morphogenetic proteins can result in significant changes not just in the skeletal armor of the stickleback, but also in the hind-limb development of humans and primates," said David Kingsley, PhD, professor of developmental biology at Stanford. "This change is likely part of the reason why we've evolved from having a grasping hind foot like a chimp to a weight-bearing structure that allows us to walk on two legs."

Kingsley, who is also a Howard Hughes Medical Institute investigator, is the senior author of a paper describing the work that will be >published in Cell. The lead author is former Stanford postdoctoral scholar Vahan Indjeian, PhD, now head of a research group at Imperial College London.

Adapting to different environments

The threespine stickleback is remarkable in that it has evolved to have many different body structures to equip it for life in different parts of the world. It sports an exterior of bony plates and spines that act as armor to protect it from predators. In marine environments, the plates are large and thick; in freshwater, the fish have evolved to have smaller, lighter-weight plates, perhaps to enhance buoyancy, increase body flexibility and better slip out of the grasp of large, hungry insects. Kingsley and his colleagues wanted to identify the regions of the fish's genome responsible for the skeletal differences that have evolved in natural populations.

The researchers identified the area of the genome responsible for controlling armor plate size, and then looked for differences there in 11 pairs of marine and freshwater fish with varying armor-plate sizes. They homed in on a region that includes the gene for a bone morphogenetic protein family member called GDF6. Due to changes in the regulatory DNA sequence near this gene, freshwater sticklebacks express higher levels of GDF6, while their saltwater cousins express less. Strikingly, marine fish genetically engineered to contain the regulatory sequence of freshwater fish expressed higher levels of GDF6 and developed smaller armor plates, the researchers found.

Regulatory regions in humans vs. chimps

Kingsley and his colleagues wondered whether changes in GDF6 expression levels might also have contributed to critical skeletal modifications during human evolution. The possibility was not as far-fetched as it might seem. Other studies by evolutionary biologists, including Kingsley, have shown that small changes in the regulatory regions of key developmental genes can have profound effects in many vertebrates.

They began by working with colleagues in the laboratory of Gill Bejerano, PhD, Stanford associate professor of developmental biology, of computer science and of pediatrics, to compare differences in the genomes of chimps and humans. In previous surveys, they found over 500 places in which humans have lost regulatory regions that are conserved from chimps and many other mammals. Two of these occur near the GDF6 gene. They homed in on one in particular.

"This regulatory information was shared through about 100 million years of evolution," said Kingsley. "And yet, surprisingly, this region is missing in humans."

To learn more about what the GDF6 regulatory region might be controlling, the researchers used the chimp regulatory DNA to control the production of a protein that is easy to visualize in mice. Laboratory mice with the chimp regulatory DNA coupled to the reporter protein strongly and specifically expressed the protein in their hind limbs, but not their forelimbs, and in their lateral toes, but not the big toes of the hind limbs. Mice genetically engineered to lack the ability to produce GDF6 in any part of their bodies had skull bones that were smaller than normal and their toes were shorter than those of their peers. Together, these findings gave the researchers a clue that GDF6 might play a critical role in limb development and evolution.

The big toe: an explanation

The fact that humans are missing the hind-limb-regulatory region probably means that we express less of the gene in our legs and feet during development, but comparable amounts in our nascent arms, hands and skulls. Loss of this particular regulatory sequence would also shorten lateral toes but not the first toe of feet. This may help explain why the big toe is aligned with other short, lateral toes in humans. Such a modification would create a more sturdy foot with which to walk upright.

"These bone morphogenetic proteins are strong signals for bone and cartilage growth in all types of animals," said Kingsley.

"You can evolve new skeletal structures by changing where and when the signals are expressed, and it's very satisfying to see similar regulatory principles in action whether you are changing the armor of a stickleback, or changing specific hind-limb structures during human evolution."

Author: Krista Conger | Source: Stanford University Medical Center [January 07, 2016]

The world's attention is now on Proxima Centauri b, a possibly Earth-like planet orbiting the closest star, 4.22 light-years away. The planet's orbit is just right to allow liquid water on its surface, needed for life. But could it in fact be habitable?

If life is possible there, the planet evolved very different than Earth, say researchers at the University of Washington-based Virtual Planetary Laboratory (VPL) where astronomers, geophysicists, climatologists, evolutionary biologists and others team to study how distant planets might host life.

Astronomers at Queen Mary University in London have announced discovery of Proxima Centauri b, a planet orbiting close to a star 4.22 light-years away. The find has been called "the biggest exoplanet discovery since the discovery of exoplanets."

Rory Barnes, UW research assistant professor of astronomy, published a discussion about the discovery at palereddot.org, a website dedicated to the search for life around Proxima Centauri. His essay describes research underway through the UW planetary lab -- part of the NASA Astrobiology Institute -- to answer the question, is life possible on this world?

"The short answer is, it's complicated," Barnes writes. "Our observations are few, and what we do know allows for a dizzying array of possibilities" -- and almost as many questions.

The Virtual Planetary Laboratory is directed by Victoria Meadows, UW professor of astronomy. UW-affiliated researchers include Giada Arney, Edward Schwieterman and Rodrigo Luger. Using computer models, the researchers studied clues from the orbits of the planet, its system, its host star and apparent companion stars Alpha Centauri A and B -- plus what is known of stellar evolution to begin evaluating Proxima b's chances.

Relatively little is known about Proxima:

• It's at least as massive as Earth and may be several times more massive, and its "year" -- the time it takes to orbit its star -- is only 11 days

• Its star is only 12 percent as massive as our sun and much dimmer (so its habitable zone, allowing liquid water on the surface, is much closer in) and the planet is 25 times closer in than Earth is to our sun

• The star may form a third part of the Alpha Centauri binary star system, separated by a distance of 15,000 "astronomical units," which could affect the planet's orbit and history

• The new data hint at the existence of a second planet in the system with an orbital period near 200 days, but this has not been proven

Perhaps the biggest obstacle to life on the planet, Barnes writes, is the brightness of its host star. Proxima Centauri, a red dwarf star, is comparatively dim, but wasn't always so.

"Proxima's brightness evolution has been slow and complicated," Barnes writes. "Stellar evolution models all predict that for the first one billion years Proxima slowly dimmed to its current brightness, which implies that for about the first quarter of a billion years, planet b's surface would have been too hot for Earth-like conditions."

Barnes notes that he and UW graduate student Rodrigo Luger recently showed that had modern Earth been in such a situation, "it would have become a Venus-like world, in a runaway greenhouse state that can destroy all of the planet's primordial water," thus extinguishing any chance for life.

Next come a host of questions about the planet's makeup, location and history, and the team's work toward discerning answers.

• Is the planet "rocky" like Earth? Most orbits simulated by the planetary lab suggest it could be -- and thus can host water in liquid form, a prerequisite for life

• Where did it form, and was there water? Whether it formed in place or farther from its star, where ice is more likely, VPL researchers believe it is "entirely possible" Proxima b could be water-rich, though they are not certain.

• Did it start out as a hydrogen-enveloped Neptune-like planet and then lose its hydrogen to become Earth-like? VPL research shows this is indeed possible, and could be a viable pathway to habitability

• Proxima Centauri flares more often than our sun; might such flares have long-since burned away atmospheric ozone that might protect the surface and any life? This is possible, though a strong magnetic field, as Earth has, could protect the surface.

Also, any life under even a few meters of liquid water would be protected from radiation.

Another concern is that the planet might be tidally locked, meaning one side permanently faces its star, as the moon does Earth. Astronomers long thought this to mean a world could not support life, but now believe planetwide atmospheric winds would transport heat around the planet.

"These questions are central to unlocking Proxima's potential habitability and determining if our nearest galactic neighbor is an inhospitable wasteland, an inhabited planet, or a future home for humanity," Barnes writes.

Planetary laboratory researchers also are developing techniques to determine whether Proxima b's atmosphere is amenable to life.

"Nearly all the components of an atmosphere imprint their presence in a spectrum (of light)," Barnes writes. "So with our knowledge of the possible histories of this planet, we can begin to develop instruments and plan observations that pinpoint the critical differences."

At high enough pressures, he notes, oxygen molecules can momentarily bind to each other to produce an observable feature in the light spectrum.

"Crucially, the pressures required to be detectable are large enough to discriminate between a planet with too much oxygen, and one with just the right amount for life.

As we learn more about the planet and the system, we can build a library of possible spectra from which to quantitatively determine how likely it is that life exists on planet b."

Our own sun is expected to burn out in about 4 billion years, but Proxima Centauri has a much better forecast, perhaps burning for 4 trillion years longer.

"If Proxima b is habitable, then it might be an ideal place to move. Perhaps we have just discovered a future home for humanity. But in order to know for sure, we must make more observations, run many more computer simulations and, hopefully, send probes to perform the first direct reconnaissance of an exoplanet," Barnes writes. "The challenges are huge, but Proxima b offers a bounty of possibilities that fills me with wonder."

Proxima Centauri b may be the first exoplanet to be directly characterized by powerful ground- and space-based telescopes planned for the future, and its atmosphere spectroscopically probed for active biology. The research was funded by the NASA Astrobiology Institute. "Whether habitable or not," Barnes concludes, "Proxima Centauri b offers a new glimpse into how the planets and life fit into our universe."

Author: Peter Kelley | Source: University of Washington [August 30, 2016]

A new study presents evidence that the rise of atmospheric oxygenation did indeed occur 2.4-2.1 billion years ago. It also shows that biological usage of copper became prominent after the so called 'Great Oxidation Event.' An international team of researchers has recently published the study in the Proceedings of the National Academy of Sciences.

"Our findings make it possible to reconstruct nutrient content in early marine settings and demonstrate that the iron-rich content of the early oceans must have severely restricted the availability of nutrients important for life", says Dr Ernest Chi Fru of Stockholm University, who has led the research group.

The study suggests a gradual shift in mainly negative copper isotopic composition of marine carbon-rich sediments, beginning at 2.4 billion years ago (Ga), to permanently positive values after 2.3 Ga. The authors argue that the change reflects the drawn-out nature of the Great Oxidation Event (GOE), when atmospheric oxygen content went from virtually nothing, starting at 2.4 Ga, to peak at near present day levels by 2.3 Ga.

Fundamentally, the high iron content of the early oceans are suggested to have played a critical role in determining trace metal availability, whereby copper levels increased when decreasing marine iron content fell by about 1 000 times after the GOE. The research has been made by examining carbon-rich rocks deposited at the bottom of ancient oceans 2.66-2.1 billion years ago.

"The appearance of oxygen in the atmosphere is one of the most important changes in Earth's geological history that enabled the evolution of oxygen based life. Understanding the chemistry of the very early oceans and how nutrients were made available, guide our steps towards understanding the processes that govern our own evolution", says Dr Ernest Chi Fru of Stockholm University.

The study provides a tool for tracking how oxygen levels have fluctuated through Earth's history and the evolutionary changes that accompanied these fluctuations.

"Our study is highlighting how the isotopic ratios of copper can unlock the evolution of Earth's early oceans from being oxygen-poor to more like they are today. We now hope to apply this technique to understanding other major geological events in the Earth's history", says Professor Dominik Weiss, co-author from Imperial College London.

Source: Stockholm University [April 18, 2016]

Genes that drive the shape of human noses have been identified by a UCL-led study. The four genes mainly affect the width and 'pointiness' of noses which vary greatly between different populations. The new information adds to our understanding of how the human face evolved and may help contribute to forensic DNA technologies that build visual profiles based on an individual's genetic makeup.

The study, published today in >Nature Communications, analysed a population of over 6,000 people with varied ancestry across Latin America to study the differences in normal facial features and identify the genes which control the shape of the nose and chin.

The researchers identified five genes which play a role in controlling the shape of specific facial features. DCHS2, RUNX2, GLI3 and PAX1 affect the width and pointiness of the nose and another gene -- EDAR -- affects chin protrusion.

"Few studies have looked at how normal facial features develop and those that have only looked at European populations, which show less diversity than the group we studied. What we've found are specific genes which influence the shape and size of individual features, which hasn't been seen before.

"Finding out the role each gene plays helps us to piece together the evolutionary path from Neanderthal to modern humans. It brings us closer to understanding how genes influence the way we look, which is important for forensics applications," said the first author of the report, Dr Kaustubh Adhikari, UCL Cell & Developmental Biology.

People have different shaped facial features based on their genetic heritage and this is partly due to how the environment influenced the evolution of the human genome. The nose, for example, is important for regulating the temperature and humidity of the air we breathe in so developed different shapes in warmer and cooler climates.

"It has long been speculated that the shape of the nose reflects the environment in which humans evolved. For example, the comparatively narrower nose of Europeans has been proposed to represent an adaptation to a cold, dry climate. Identifying genes affecting nose shape provides us with new tools to examine this question, as well as the evolution of the face in other species. It may also help us understand what goes wrong in genetic disorders involving facial abnormalities," explained Professor Andrés Ruiz-Linares UCL Biosciences, who led the study.

The team collected and analysed DNA samples from 6,630 volunteers from the CANDELA cohort recruited in Brazil, Colombia, Chile, Mexico and Peru. After an initial screen, a sample size of 5,958 was used. This group included individuals of mixed European (50%), Native American (45%) and African (5%) ancestry, resulting in a large variation in facial features.

Both men and women were assessed for 14 different facial features and whole genome analysis identified the genes driving differences in appearance.

A subgroup of 3,000 individuals had their features assessed using a 3D reconstruction of the face in order to obtain exact measurements of facial features and the results identified the same genes.

The study identified genes that are involved in bone and cartilage growth and the development of the face. GLI3, DCHS2 and PAX1 are all genes known to drive cartilage growth -- GLI3 gave the strongest signal for controlling the breadth of nostrils, DCHS2 was found to control nose 'pointiness' and PAX1 also influences nostril breadth. RUNX2 which drives bone growth was seen to control nose bridge width.

The genes GLI3, DCHS2 and RUNX2 are known to show strong signals of recent selection in modern humans compared to archaic humans such as Neanderthals and Denisovans; GLI3 in particular undergoing rapid evolution.

Source: University College London [May 19, 2016]

A team of researchers has discovered the fossil of a 305-million-year-old arachnid, which will help scientists to understand more about the early origins of modern-day spiders.

The new species, named Idmonarachne brasieri in honour of Professor Martin Brasier, University of Oxford, who passed away in December 2014, was found in Montceau-les-Mines, France, and researchers from The University of Manchester, Berlin's Museum fur Naturkunde, the University of Kansas and Imperial College London have worked with the Natural History Museum and the UK's Diamond Light Source to scan and examine the fossil in detail.

Details of the origins of spiders remain limited, with little knowledge of their predecessors and no insights into character acquisition early in their evolution. This fossil was preserved in 3D, which enabled the researchers to investigate its minute anatomical details.

We have known since 2008 that a group called the uraraneids were a sister group to true spiders -- they could make silk, but probably laid it down in sheets, rather than spinning it as modern spiders do. They also had a tail-like structure at the end called a flagellum.

Analysis of Idmonarachne brasieri suggests that as the spider lineage evolved, the animals lost their tail-like structure, and developed spider-like fangs and limbs. Whilst they could likely make silk, the ancestors lacked the ability to spin it using specialised appendages called spinnerets. These are the features that define true spiders, and give them more control over the use and distribution of silk.

Lead author Russell Garwood, of The University of Manchester's School of Earth, Atmospheric & Environmental Sciences, said, "Our new fossil occupies a key position in the evolution of spiders. It isn't a true spider, but has given us new information regarding the order in which the bits of the anatomy we associate with spiders appeared as the group evolved."

This is part of an ongoing effort to look at early arachnids, and see what this can tell us about the early evolution of the group, how they came onto land and what their evolutionary tree looks like. Arachnids as a whole are a very diverse group, but working out how they are all related to each other has proved a challenge. The authors hope that by better understanding these fossils, they can help fill in some of the blanks.

The discovery is published in the Proceedings of the Royal Society B.

Source: University of Manchester [March 31, 2016]

For each ton of carbon dioxide (CO2) that any person on our planet emits, 3 m² of Arctic summer sea ice disappear. This is the finding of a new study that has been published in the journal Science this week by Dr. Dirk Notz, leader of Max Planck research group "Sea Ice in the Earth System" at the Max Planck Institute for Metorology (MPI-M) and by Prof. Julienne Stroeve from the National Snow and Ice Data Centre in Boulder, Colorado, and the University College London, UK. These numbers allow one for the first time to grasp the individual contribution to global climate change. The study also explains why climate models usually simulate a lower sensitivity - and concludes that the 2 °C global warming target will not allow Arctic summer sea ice to survive.

The rapid retreat of Arctic sea ice is one of the most direct indicators of the ongoing climate change on our planet. Over the past forty years, the ice cover in summer has shrunk by more than half, with climate model simulations predicting that the remaining half might be gone by mid century unless greenhouse gas emissions are reduced rapidly. However, a number of studies have indicated that climate models underestimate the loss of Arctic sea ice, which is why the models might not be the most suitable tools to quantify the future evolution of the ice cover.

To address this issue, a new study in the >journal Science now derives the future evolution of Arctic summer sea ice directly from the observational record. To do so, the authors examine the link between carbon-dioxide emissions and the area of Arctic summer sea ice, and find that both are linearly related. "The observed numbers are very simple", explains lead author Dirk Notz. "For each ton of carbon dioxide that a person emits anywhere on this planet, 3 m² of Arctic summer sea ice disappear." And his co-author Julienne Stroeve from adds: "So far, climate change has often felt like a rather abstract notion. Our results allow us to overcome this perception. For example, it is now straight-forward to calculate that the carbon dioxide emissions for each seat on a return flight from, say, London to San Francisco causes about 5 m² of Arctic sea ice to disappear."

The study also explains the linear relationship between carbon-dioxide emissions and sea-ice loss. "Put simply, for each ton of carbon dioxide emission, the climate warms a little bit. To compensate for this warming, the sea-ice edge moves northward to a region with less incoming solar radiation. This then causes the sea-ice area to shrink. Simple geometric reasons cause these processes to combine to the observed linearity", explains Notz.

Climate models also simulate the observed linear relationship between sea-ice area and CO2 emissions. However, they usually have a much lower sensitivity of the ice cover than has been observed. The Science study finds that this is most likely because the models underestimate the atmospheric warming in the Arctic that is induced by a given carbon-dioxide emission. "It seems that it's not primarily the sea-ice models that are responsible for the mismatch. The ice just melts too slow in the models because their Arctic warming is too weak", says Stroeve.

Regarding the future evolution of Arctic sea ice, the new study finds that the internationally agreed 2 °C global warming target is not sufficient to allow Arctic summer sea ice to survive. Given the observed sensitivity of the ice cover, the sea ice is gone throughout September once another 1000 gigatons of carbon dioxide have been emitted. This amount of emissions is usually taken as a rough estimate of the allowable emissions to reach the 2 °C global-warming target. Only for the much lower emissions that would allow one to keep global warming below 1.5 °C, as called for by the Paris agreement, Arctic summer sea ice has a realistic chance of long-term survival, the study concludes. 

Source: Max Planck Society [November 04, 2016]